Sarcalumenin

Protein-coding gene in the species Homo sapiens

SRL

Identifiers

Aliases

SRL, entrez:6345, sarcalumenin, SAR

External IDs

OMIM: 604992; MGI: 2146620; HomoloGene: 45500; GeneCards: SRL; OMA:SRL - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	4,189,374 bp^[1]
Band	16p13.3	End	4,242,080 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 A1	Start	4,298,080 bp^[2]
Band	16\|16 A1	End	4,359,680 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

quadriceps femoris muscle

vastus lateralis muscle

tibialis anterior muscle

deltoid muscle

body of tongue

right ventricle

vena cava

superior surface of tongue

pericardium

Top expressed in

interventricular septum

sternocleidomastoid muscle

triceps brachii muscle

temporal muscle

vastus lateralis muscle

extraocular muscle

ankle

digastric muscle

soleus muscle

tibialis anterior muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	GTP binding
Cellular component	sarcoplasmic reticulum sarcoplasmic reticulum lumen
Biological process	store-operated calcium entry response to muscle activity involved in regulation of muscle adaptation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6345


106393

Ensembl


ENSG00000185739


ENSMUSG00000022519

UniProt


Q86TD4


Q7TQ48

RefSeq (mRNA)


NM_001098814 NM_001323667 NM_001323668


NM_175347 NM_001347162 NM_001361474

RefSeq (protein)


NP_001092284 NP_001310596 NP_001310597


NP_001334091 NP_780556 NP_001348403

Location (UCSC)

Chr 16: 4.19 – 4.24 Mb

Chr 16: 4.3 – 4.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sarcalumenin is a protein that in humans is encoded by the SRL gene.^[5]^[6]

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.^[7] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.^[8] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.^[7] Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185739 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022519 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. Bibcode:1989PNAS...86.6047L. doi:10.1073/pnas.86.16.6047. PMC 297772. PMID 2762314.
^ Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
^ ^a ^b Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576-82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.
^ Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.

External links

sarcalumenin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Adhesion molecules	Cadherins CDH1 CDH2 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CDH10 CDH11 CDH12 CDH13 CDH14 CDH15 CDH16 CDH17
Calcium channels	Ligand-gated 5-HT3 receptor Ionotropic glutamate receptors AMPA receptors Kainate receptors NMDA receptors P2X receptors Voltage-gated L N P R T TRP channels TRPA TRPC TRPV
Calcium pumps	Sodium-calcium exchangers SLC3A2 SLC8A1
GPCRs	Calcium-sensing receptor
Annexins	A1 A2 A3 A4 A5 A6 A7 A8 A8-L2 A9 A10 A11 A12 A13

Intracellular signaling

Second messengers	IP3 NAADP cADPR
Intracellular channels	IP3 receptor Ryanodine receptor Calcium-induced calcium release
Intracellular pumps	SERCA ATP2A1 ATP2A2 ATP2A3 Sodium-calcium exchangers SLC8B1 SLC24A5
Sensors and chelators	Calbindin Calmodulin CALM1 CALM2 CALM3 CALML3 CALML5 Calsequestrin Calretinin Gelsolin Neuronal calcium sensors Calsenilin Frequenin GUCA 1A 1B Hippocalcin Neurocalcin Recoverin Visinin Parvalbumin Phospholamban Sarcalumenin Synaptotagmins SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT9 SYT11 SYT13 SYT14 S100 S100P Troponin C TNNC1 TNNC2
Calcium-dependent chaperones	Calreticulin Calnexin HSPA5 HSP90B1
Calcium-dependent kinases	CaM kinases CAMK1 CAMK2 A B D G CAMK3 CAMK4 Protein kinase C
Calcium-dependent proteases	Calpains CAPN1 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10
Indirect regulators	Calcitonin Parathyroid hormone Vitamin D Vitamin K

Extracellular chelators

Extracellular matrix proteins	Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein Dentin sialophosphoprotein Osteopontin
Secreted hormones	Osteocalcin