CDH9

Protein-coding gene in the species Homo sapiens
CDH9
Identifiers
AliasesCDH9, cadherin 9
External IDsOMIM: 609974; MGI: 107433; HomoloGene: 9450; GeneCards: CDH9; OMA:CDH9 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDH9
Genomic location for CDH9
Band5p14.1Start26,880,597 bp[1]
End27,121,150 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CDH9
Genomic location for CDH9
Band15|15 A2Start16,728,842 bp[2]
End16,857,180 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • prefrontal cortex

  • testicle

  • dorsolateral prefrontal cortex

  • anterior cingulate cortex

  • Brodmann area 9

  • right frontal lobe

  • nucleus accumbens

  • Brodmann area 23

  • middle temporal gyrus
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • supraoptic nucleus

  • lumbar spinal ganglion

  • temporal lobe

  • hippocampus proper

  • anterior amygdaloid area

  • prefrontal cortex

  • barrel cortex

  • subiculum

  • substantia nigra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • metal ion binding
  • molecular function
  • cytoskeletal protein binding
  • protein homodimerization activity
  • cadherin binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of postsynaptic membrane
  • integral component of presynaptic membrane
  • cell surface
  • catenin complex
Biological process
  • cell adhesion
  • adherens junction organization
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • cell-cell adhesion
  • synapse assembly
  • synaptic membrane adhesion
  • cell-cell junction assembly
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
  • cell-cell adhesion mediated by cadherin
  • cell morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1007

12565

Ensembl

ENSG00000113100

ENSMUSG00000025370

UniProt

Q9ULB4

P70407

RefSeq (mRNA)

NM_016279

NM_009869

RefSeq (protein)

NP_057363

NP_033999

Location (UCSC)Chr 5: 26.88 – 27.12 MbChr 15: 16.73 – 16.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.[5][6]

Clinical significance

An association with autism has been suggested.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113100 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025370 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: cadherin 9".
  6. ^ Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regulation. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
  7. ^ Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

External links

Further reading

  • Nollet F, Kools P, van Roy F (June 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". Journal of Molecular Biology. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
  • Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (July 2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". The Biochemical Journal. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
  • Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–59. doi:10.1038/mp.2010.107. PMC 3859494. PMID 21079607.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ali J, Liao F, Martens E, Muller WA (June 1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219. S2CID 21501093.
  • Thedieck C, Kalbacher H, Kuczyk M, Müller GA, Müller CA, Klein G (2007). Zoccali C (ed.). "Cadherin-9 is a novel cell surface marker for the heterogeneous pool of renal fibroblasts". PLOS ONE. 2 (7): e657. Bibcode:2007PLoSO...2..657T. doi:10.1371/journal.pone.0000657. PMC 1924602. PMID 17668045. Open access icon
  • Hülsken J, Birchmeier W, Behrens J (December 1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". The Journal of Cell Biology. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.


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