SYT3

Protein-coding gene in the species Homo sapiens
SYT3
Identifiers
AliasesSYT3, SytIII, synaptotagmin 3
External IDsOMIM: 600327 MGI: 99665 HomoloGene: 9617 GeneCards: SYT3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SYT3
Genomic location for SYT3
Band19q13.33Start50,621,307 bp[1]
End50,639,881 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SYT3
Genomic location for SYT3
Band7 B3|7 28.83 cMStart44,033,526 bp[2]
End44,049,611 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superior frontal gyrus

  • prefrontal cortex

  • Brodmann area 9

  • hippocampus proper

  • hypothalamus

  • temporal lobe

  • amygdala

  • nucleus accumbens

  • putamen

  • caudate nucleus
Top expressed in
  • superior frontal gyrus

  • cerebellar cortex

  • entorhinal cortex

  • medulla oblongata

  • hippocampus proper

  • inferior colliculus

  • pons

  • superior colliculus

  • primary motor cortex

  • pontine nuclei
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • clathrin binding
  • calcium ion binding
  • metal ion binding
  • calcium-dependent phospholipid binding
  • syntaxin binding
  • SNARE binding
  • phosphatidylserine binding
Cellular component
  • integral component of membrane
  • endosome
  • transport vesicle membrane
  • membrane
  • cytoplasmic vesicle
  • presynapse
  • plasma membrane
  • synapse
  • exocytic vesicle
Biological process
  • positive regulation of dendrite extension
  • cell differentiation
  • calcium-ion regulated exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • regulation of calcium ion-dependent exocytosis
  • vesicle fusion
  • regulation of dopamine secretion
  • synaptic vesicle exocytosis
  • vesicle-mediated transport
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84258

20981

Ensembl

ENSG00000213023

ENSMUSG00000030731

UniProt

Q9BQG1

O35681

RefSeq (mRNA)

NM_001160328
NM_001160329
NM_032298

NM_001114116
NM_016663

RefSeq (protein)
NP_001153800
NP_001153801
NP_115674
NP_001153800.1
NP_001153801.1

NP_115674.1

NP_001107588
NP_057872

Location (UCSC)Chr 19: 50.62 – 50.64 MbChr 7: 44.03 – 44.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213023 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030731 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19" (PDF). Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.
  6. ^ "Entrez Gene: SYT3 synaptotagmin III".

Further reading

  • Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
  • Fukuda M, Kanno E, Mikoshiba K (October 1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". The Journal of Biological Chemistry. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
  • Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry. 275 (9): 6328–36. doi:10.1074/jbc.275.9.6328. PMID 10692432.
  • Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • v
  • t
  • e
  • 1dqv: CRYSTAL STRUCTURE OF SYNAPTOTAGMIN III C2A/C2B
    1dqv: CRYSTAL STRUCTURE OF SYNAPTOTAGMIN III C2A/C2B
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPI
COPII
RME/Clathrin
Caveolae
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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