CDH6

Protein-coding gene in the species Homo sapiens

CDH6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3LND

Identifiers
AliasesCDH6, CAD6, KCAD, cadherin 6
External IDsOMIM: 603007; MGI: 107435; HomoloGene: 21027; GeneCards: CDH6; OMA:CDH6 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDH6
Genomic location for CDH6
Band5p13.3Start31,193,686 bp[1]
End31,329,146 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CDH6
Genomic location for CDH6
Band15|15 A1Start13,028,787 bp[2]
End13,173,761 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney tubule

  • kidney

  • endothelial cell

  • vena cava

  • gallbladder

  • sural nerve

  • metanephric glomerulus

  • visceral pleura

  • putamen

  • Brodmann area 46
Top expressed in
  • internal carotid artery

  • external carotid artery

  • hair follicle

  • ascending aorta

  • aortic valve

  • renal corpuscle

  • ciliary body

  • iris

  • ureter

  • facial motor nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • metal ion binding
  • cytoskeletal protein binding
  • protein homodimerization activity
  • cadherin binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • cell surface
  • catenin complex
Biological process
  • Notch signaling pathway
  • cell adhesion
  • adherens junction organization
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • cell-cell junction assembly
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
  • cell-cell adhesion mediated by cadherin
  • cell-cell adhesion
  • cell morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1004

12563

Ensembl

ENSG00000113361

ENSMUSG00000039385

UniProt

P55285

P97326

RefSeq (mRNA)

NM_004932
NM_001362435

NM_007666

RefSeq (protein)

NP_004923
NP_001349364

NP_031692

Location (UCSC)Chr 5: 31.19 – 31.33 MbChr 15: 13.03 – 13.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.[5][6][7]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113361 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039385 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID 7743525.
  6. ^ Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
  7. ^ a b "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

Further reading

  • MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation". Am. J. Reprod. Immunol. 39 (2): 96–107. doi:10.1111/j.1600-0897.1998.tb00341.x. PMID 9506208. S2CID 23871813.
  • Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
  • Paul R, Ewing CM, Robinson JC, et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma". Cancer Res. 57 (13): 2741–8. PMID 9205085.
  • Getsios S, Chen GT, Stephenson MD, et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111. S2CID 43022919.
  • Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  • Shimoyama Y, Takeda H, Yoshihara S, et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin". J. Biol. Chem. 274 (17): 11987–94. doi:10.1074/jbc.274.17.11987. PMID 10207020.
  • Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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