SLC8B1

Protein-coding gene in the species Homo sapiens
SLC8B1
Identifiers
AliasesSLC8B1, NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1
External IDsOMIM: 609841; MGI: 2180781; HomoloGene: 41602; GeneCards: SLC8B1; OMA:SLC8B1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLC8B1
Genomic location for SLC8B1
Band12q24.13Start113,298,759 bp[1]
End113,359,493 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SLC8B1
Genomic location for SLC8B1
Band5|5 FStart120,649,233 bp[2]
End120,672,089 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left adrenal cortex

  • right adrenal gland

  • right adrenal cortex

  • left ovary

  • right ovary

  • spleen

  • mucosa of transverse colon

  • sural nerve

  • granulocyte

  • epithelium of colon
Top expressed in
  • granulocyte

  • stroma of bone marrow

  • decidua

  • left lobe of liver

  • lip

  • tibiofemoral joint

  • yolk sac

  • left colon

  • gastrula

  • mesenteric lymph nodes
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein homodimerization activity
  • identical protein binding
  • antiporter activity
  • calcium:cation antiporter activity
  • calcium:sodium antiporter activity
  • calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • mitochondrial crista
  • mitochondrion
  • integral component of mitochondrial membrane
  • sarcolemma
  • mitochondrial inner membrane
Biological process
  • sodium ion transmembrane transport
  • regulation of cytosolic calcium ion concentration
  • glucose homeostasis
  • response to stimulus
  • regulation of insulin secretion
  • sodium ion transport
  • ion transport
  • calcium ion transmembrane transport
  • regulation of cardiac muscle cell membrane potential
  • calcium ion transport
  • transmembrane transport
  • mitochondrial calcium ion transmembrane transport
  • mitochondrial calcium ion homeostasis
  • calcium export from the mitochondrion
  • regulation of lymphocyte chemotaxis
  • regulation of store-operated calcium entry
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80024

170756

Ensembl

ENSG00000089060

ENSMUSG00000032754

UniProt

Q6J4K2

Q925Q3

RefSeq (mRNA)

NM_024959
NM_001330466
NM_001358345

NM_001177594
NM_001177595
NM_133221

RefSeq (protein)

NP_001317395
NP_079235
NP_001345274

NP_001171065
NP_001171066
NP_573484

Location (UCSC)Chr 12: 113.3 – 113.36 MbChr 5: 120.65 – 120.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.[5]

Function

SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089060 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032754 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
  6. ^ Cai X, Lytton J (February 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Further reading

  • Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (June 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
  • Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (June 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
  • Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (October 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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