Protein-coding gene in the species Homo sapiens
| SYT6 |
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| Identifiers |
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| Aliases | SYT6, sytVI, synaptotagmin 6 |
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| External IDs | OMIM: 607718 MGI: 1859544 HomoloGene: 10301 GeneCards: SYT6 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p13.2 | Start | 114,089,291 bp[1] |
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| End | 114,153,880 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 3 (mouse)[2] |
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| | Band | 3|3 F2.2 | Start | 103,482,547 bp[2] |
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| End | 103,552,885 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - pancreatic ductal cell
- ganglionic eminence
- nucleus accumbens
- hypothalamus
- tibialis anterior muscle
- caudate nucleus
- putamen
- prefrontal cortex
- body of pancreas
- spinal ganglia
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| | Top expressed in | - superior frontal gyrus
- olfactory bulb
- pretectal area
- olfactory tubercle
- ganglionic eminence
- tongue
- habenula
- cerebellar cortex
- neural tube
- nucleus accumbens
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - calcium ion binding
- protein homodimerization activity
- clathrin binding
- calcium-dependent protein binding
- metal ion binding
- protein binding
- identical protein binding
- calcium-dependent phospholipid binding
- syntaxin binding
- phosphatidylserine binding
- SNARE binding
| | Cellular component | - cytoplasm
- integral component of membrane
- cytosol
- membrane
- perinuclear endoplasmic reticulum
- synapse
- synaptic vesicle membrane
- cell junction
- cytoplasmic vesicle
- plasma membrane
- extrinsic component of membrane
- glutamatergic synapse
- integral component of synaptic membrane
- exocytic vesicle
| | Biological process | - acrosomal vesicle exocytosis
- acrosome reaction
- regulation of calcium ion-dependent exocytosis
- calcium ion-regulated exocytosis of neurotransmitter
- vesicle fusion
- presynaptic dense core vesicle exocytosis
- regulation of dopamine secretion
- synaptic vesicle exocytosis
- vesicle-mediated transport
- calcium-ion regulated exocytosis
- cellular response to calcium ion
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | NM_001253772
NM_001270805
NM_205848
NM_001366223
NM_001366224
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NM_001366225
NM_001366226 |
| NM_001276676
NM_001276677
NM_001276679
NM_001276680
NM_001276681
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NM_018800 |
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| RefSeq (protein) | NP_001257734
NP_995320
NP_001240701
NP_001353152
NP_001353153
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NP_001353154
NP_001353155 |
| NP_001263605
NP_001263606
NP_001263608
NP_001263609
NP_001263610
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NP_061270 |
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| Location (UCSC) | Chr 1: 114.09 – 114.15 Mb | Chr 3: 103.48 – 103.55 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.[5][6]
Function
Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134207 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027849 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
- ^ a b "Entrez Gene: SYT6 synaptotagmin VI".
Further reading
- Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Developmental Biology. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
- Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
- Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
- Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
