SYT2

Protein-coding gene in the species Homo sapiens
SYT2
Identifiers
AliasesSYT2, SytII, CMS7, MYSPC, synaptotagmin 2, CMS7A, CMS7B
External IDsOMIM: 600104 MGI: 99666 HomoloGene: 22516 GeneCards: SYT2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SYT2
Genomic location for SYT2
Band1q32.1Start202,590,596 bp[1]
End202,710,454 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for SYT2
Genomic location for SYT2
Band1 E4|1 58.24 cMStart134,574,415 bp[2]
End134,690,331 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pons

  • external globus pallidus

  • cerebellar vermis

  • superior vestibular nucleus

  • inferior olivary nucleus

  • spinal ganglia

  • ventral tegmental area

  • inferior ganglion of vagus nerve

  • postcentral gyrus

  • Brodmann area 23
Top expressed in
  • cerebellar cortex

  • inferior colliculus

  • medulla oblongata

  • pontine nuclei

  • medial vestibular nucleus

  • facial motor nucleus

  • anterior horn of spinal cord

  • cerebellar vermis

  • dorsal tegmental nucleus

  • superior colliculus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • calcium ion binding
  • inositol 1,3,4,5 tetrakisphosphate binding
  • clathrin binding
  • syntaxin binding
  • protein binding
  • calcium-dependent phospholipid binding
  • SNARE binding
  • phosphatidylserine binding
Cellular component
  • cell junction
  • chromaffin granule membrane
  • synaptic vesicle
  • membrane
  • cytoplasmic vesicle
  • synapse
  • integral component of membrane
  • synaptic vesicle membrane
  • plasma membrane
  • clathrin-coated vesicle membrane
  • axon
  • dense core granule
  • exocytic vesicle
Biological process
  • synaptic vesicle endocytosis
  • cell differentiation
  • neurotransmitter secretion
  • positive regulation of dendrite extension
  • vesicle fusion
  • regulation of calcium ion-dependent exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • membrane organization
  • regulation of dopamine secretion
  • synaptic vesicle exocytosis
  • vesicle-mediated transport
  • calcium-ion regulated exocytosis
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

127833

20980

Ensembl

ENSG00000143858

ENSMUSG00000026452

UniProt

Q8N9I0

P46097

RefSeq (mRNA)

NM_001136504
NM_177402

NM_009307
NM_001355726

RefSeq (protein)

NP_001129976
NP_796376

NP_033333
NP_001342655

Location (UCSC)Chr 1: 202.59 – 202.71 MbChr 1: 134.57 – 134.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.
  6. ^ "Entrez Gene: SYT2 synaptotagmin II".

Further reading

  • Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". The Journal of Biological Chemistry. 269 (46): 29206–11. doi:10.1016/S0021-9258(19)62031-4. PMID 7961887.
  • Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
  • Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells". The Journal of Experimental Medicine. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
  • Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  • Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum". The Journal of Cell Biology. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
  • Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
  • Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Letters. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368. S2CID 29026112.
  • Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
  • Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". The Journal of Biological Chemistry. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
  • Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Molecular Cell. 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders
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