Nifekalant

Chemical compound
  • none
Legal statusLegal status
  • In general: ℞ (Prescription only)
Identifiers
  • 6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
CAS Number
  • 130636-43-0 checkY
PubChem CID
  • 4486
ChemSpider
  • 4331
UNII
  • 5VZ7GZM43E
CompTox Dashboard (EPA)
  • DTXSID7048374 Edit this at Wikidata
Chemical and physical dataFormulaC19H27N5O5Molar mass405.455 g·mol−13D model (JSmol)
  • Interactive image
  • Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O
InChI
  • InChI=1S/C19H27N5O5/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29/h5-8,14,20,25H,3-4,9-13H2,1-2H3
  • Key:OEBPANQZQGQPHF-UHFFFAOYSA-N
  (verify)

Nifekalant (INN) is a class III antiarrhythmic agent approved in Japan for the treatment of arrhythmias and ventricular tachycardia.[1] It has the brand name Shinbit.

References

  1. ^ Oyabe A, Sano H (February 2002). "Pharmacological and clinical profile of nifekalant (shinbit injection), a class III antiarrhythmic drug". Nippon Yakurigaku Zasshi. 119 (2): 103–9. doi:10.1254/fpj.119.103. PMID 11862758.
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Ion channel modulators
Calcium
VDCCsTooltip Voltage-dependent calcium channels
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IRKsTooltip Inwardly rectifying potassium channel
Blockers
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  • GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
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Blockers
  • BKCa-specific: Ethanol (alcohol)
  • GAL-021
Activators
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  • See here instead.
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators
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Channel blockers
class I
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class Ia (Phase 0→ and Phase 3→)
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