Bunaftine

Chemical compound
  • C01BD03 (WHO)
Identifiers
  • N-[2-(Diethylamino)ethyl]-N-propylnaphthalene-1-carboxamide
CAS Number
  • 32421-46-8 checkY
PubChem CID
  • 36131
ChemSpider
  • 33233 checkY
UNII
  • GH09PRQ3FU
KEGG
  • D07428 checkY
ChEMBL
  • ChEMBL2104200
CompTox Dashboard (EPA)
  • DTXSID90186165 Edit this at Wikidata
ECHA InfoCard100.046.373 Edit this at WikidataChemical and physical dataFormulaC21H30N2OMolar mass326.484 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12
InChI
  • InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3 checkY
  • Key:WWGZXRYELYWJBD-UHFFFAOYSA-N checkY
  (verify)

Bunaftine (or bunaphtine[1]) is an antiarrhythmic agent.[2] It is classified in class III.[3]

References

  1. ^ Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.
  2. ^ Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi:10.1536/ihj.24.377. PMID 6876382.
  3. ^ Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317. PMID 328029.
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Ion channel modulators
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
  • GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
KCaTooltip Calcium-activated potassium channel
Blockers
  • BKCa-specific: Ethanol (alcohol)
  • GAL-021
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
  • Solnatide
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
  • See here instead.
LGICsTooltip Ligand gated ion channels
  • See here instead.
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
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Channel blockers
class I
(Na+ channel blockers)
class Ia (Phase 0→ and Phase 3→)
class Ib (Phase 3←)
class Ic (Phase 0→)
class III
(Phase 3→, K+ channel blockers)
class IV
(Phase 4→, Ca2+ channel blockers)
Receptor agonists
and antagonists
class II
(Phase 4→, β blockers)
A1 agonist
M2
α receptors
Ion transporters
Na+/ K+-ATPase


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