Cinchocaine
Local anaesthetic drug
- C05AD04 (WHO) D04AB02 (WHO) N01BB06 (WHO) S01HA06 (WHO) S02DA04 (WHO)
- US: OTC
- 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
- 85-79-0
Y
- 3025
- 7159
- DB00527 Y
- 2917 Y
- L6JW2TJG99
- D00733 Y
- CHEBI:247956 Y
- ChEMBL1086 Y
- DTXSID3045271
- Interactive image
- O=C(c1c2ccccc2nc(OCCCC)c1)NCCN(CC)CC
- InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)Y
- Key:PUFQVTATUTYEAL-UHFFFAOYSA-NY
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl.[3] It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
See also
References
Further reading
- Abdel-Ghani NT, Youssef AF, Awady MA (May 2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco. 60 (5): 419–424. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padrón T, Lima AP, Ribeiro Rd (September 2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitology Research. 99 (4): 317–320. doi:10.1007/s00436-006-0192-1. PMID 16612626. S2CID 5933459.
- Nounou MM, El-Khordagui LK, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Poloniae Pharmaceutica. 62 (5): 369–379. PMID 16459486.
- Aroti A, Leontidis E (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment". Journal of Chemical Education. 78 (6): 786–788. Bibcode:2001JChEd..78..786A. doi:10.1021/ed078p786.
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