Antihypertensive drug of the calcium channel blocker class
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Legal status | - In general: ℞ (Prescription only)
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Identifiers |
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(±)-2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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CompTox Dashboard (EPA) | - DTXSID2043745
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Chemical and physical data |
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Formula | C35H38N4O6 |
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Molar mass | 610.711 g·mol−1 |
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3D model (JSmol) | |
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InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3 |
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.[1][2][3][4][5]
It was patented in 1982 and approved for medical use in 1990.[6]
References
- ^ Cheer SM, McClellan K (2001). "Manidipine: a review of its use in hypertension". Drugs. 61 (12): 1777–1799. doi:10.2165/00003495-200161120-00010. PMID 11693466. S2CID 260814599. Archived from the original on 2013-01-17. Retrieved 2009-06-20.
- ^ McKeage K, Scott LJ (2004). "Manidipine: a review of its use in the management of hypertension". Drugs. 64 (17): 1923–1940. doi:10.2165/00003495-200464170-00011. PMID 15329044. S2CID 195689527. Archived from the original on 2013-01-16. Retrieved 2009-06-20.
- ^ Roca-Cusachs A, Triposkiadis F (2005). "Antihypertensive effect of manidipine". Drugs. 65 (Suppl 2): 11–19. doi:10.2165/00003495-200565002-00003. PMID 16398058. S2CID 25854593. Archived from the original on 2013-01-16. Retrieved 2009-06-20.
- ^ Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–263. PMC 2293964. PMID 17703633.
- ^ Mizuno K, Haga H, Takahashi M, Fukuchi S (August 1992). "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders". Current Therapeutic Research. 52 (2): 248–253. doi:10.1016/S0011-393X(05)80475-8.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495.
Ion channel modulators
Calcium | VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium | VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | Blockers | |
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Activators | - GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium | VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride | CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others | TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators |
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Simple piperazines (no additional rings) | |
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Phenylpiperazines | - 2C-B-PP
- 3,4-CFP
- Acaprazine
- Antrafenine
- Aripiprazole
- Batoprazine
- Bifeprunox
- BRL-15,572
- Ciprofloxacin
- CSP-2503
- Dapiprazole
- DCPP
- DMPP
- Diphenylpiperazine
- Dropropizine
- EGIS-12,233
- Elopiprazole
- Eltoprazine
- Enpiprazole
- Ensaculin
- Etoperidone
- Flesinoxan
- Fluanisone
- Flibanserin
- Fluprazine
- Itraconazole
- Ketoconazole
- Levodropropizine
- Lorpiprazole
- mCPP
- Mefway
- MeOPP
- Mepiprazole
- Naftopidil
- Naluzotan
- Naphthylpiperazine
- Nefazodone
- Niaprazine
- Oxypertine
- Pardoprunox
- pCPP
- pFPP
- Posaconazole
- S-14,506
- S-14,671
- S-15,535
- SB-258,585
- SB-271,046
- SB-357,134
- SB-399,885
- Sonepiprazole
- TFMPP
- Tolpiprazole
- Trazodone
- Urapidil
- Vesnarinone
- Vilazodone
- Vortioxetine
- WAY-100,135
- WAY-100,635
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Benzylpiperazines | |
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Diphenylalkylpiperazines (benzhydrylalkylpiperazines) | |
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Pyrimidinylpiperazines | |
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Pyridinylpiperazines | |
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Benzo(iso)thiazolylpiperazines | |
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Tricyclics (piperazine attached via side chain) | |
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Others/Uncategorized | |
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