60S ribosomal protein L8

Protein found in humans
RPL8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4CCM, 4CCN, 4CCO, 4UG0, 4V6X, 5AJ0, 4D67, 3J7Q, 4Y3O, 4UJC, 3J7R, 4D5Y, 4UJE, 4UJD, 3J7P, 3J7O, 3J92, 4V5Z

Identifiers
AliasesRPL8, L8, ribosomal protein L8
External IDsOMIM: 604177 MGI: 1350927 HomoloGene: 32141 GeneCards: RPL8
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for RPL8
Genomic location for RPL8
Band8q24.3Start144,789,765 bp[1]
End144,792,587 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for RPL8
Genomic location for RPL8
Band15|15 D3Start76,788,278 bp[2]
End76,790,514 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ovary

  • trachea

  • thymus

  • pituitary gland

  • skin of abdomen

  • anterior pituitary

  • right uterine tube

  • stromal cell of endometrium

  • canal of the cervix

  • ganglionic eminence
Top expressed in
  • primitive streak

  • hair follicle

  • abdominal wall

  • medial ganglionic eminence

  • maxillary prominence

  • condyle

  • dermis

  • somite

  • Paneth cell

  • fossa
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • rRNA binding
  • structural constituent of ribosome
  • RNA binding
  • 5.8S rRNA binding
Cellular component
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • large ribosomal subunit
  • intracellular anatomical structure
  • cytoplasm
  • cytosolic large ribosomal subunit
  • postsynaptic density
  • polysomal ribosome
  • synapse
  • postsynapse
Biological process
  • cytoplasmic translation
  • protein biosynthesis
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • rRNA processing
  • cellular response to nerve growth factor stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6132

26961

Ensembl

ENSG00000161016

ENSMUSG00000003970

UniProt

P62917

P62918

RefSeq (mRNA)

NM_000973
NM_033301
NM_001317771
NM_001317782

NM_012053

RefSeq (protein)

NP_000964
NP_001304700
NP_001304711
NP_150644

NP_036183

Location (UCSC)Chr 8: 144.79 – 144.79 MbChr 15: 76.79 – 76.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161016 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003970 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun. 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID 7506540.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPL8 ribosomal protein L8".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Uhlein M, Weglöhner W, Urlaub H, Wittmann-Liebold B (1998). "Functional implications of ribosomal protein L2 in protein biosynthesis as shown by in vivo replacement studies". Biochem. J. 331 (2): 423–30. doi:10.1042/bj3310423. PMC 1219371. PMID 9531480.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

External links

  • Overview of all the structural information available in the PDB for UniProt: P62917 (60S ribosomal protein L8) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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