40S ribosomal protein S27a

RPS27A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KTF, 2L0F, 2L0T, 2XK5, 3AXC, 3NHE, 3NOB, 3PHW, 3TBL, 4UG0, 4V6X, 5AJ0, 4R62, 5FLX, 4UJD, 4KZZ, 4UJC, 3J7P, 4KZY, 4D5L, 3J7R, 4D61, 4KZX, 4UJE, 5A2Q
Identifiers
Aliases	RPS27A, CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, ribosomal protein S27a
External IDs	OMIM: 191343; MGI: 1925544; HomoloGene: 37715; GeneCards: RPS27A; OMA:RPS27A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.1 Start 55,231,903 bp[1] End 55,235,853 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A3.3 Start 29,495,846 bp[2] End 29,498,109 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube canal of the cervix left lobe of thyroid gland anterior pituitary right lobe of thyroid gland left uterine tube gastric mucosa right lung body of stomach Top expressed in urinary bladder bone marrow uterus pancreas adrenal gland lens thymus islet of Langerhans ganglionic eminence lip More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding structural constituent of ribosome protein binding RNA binding protein tag ubiquitin protein ligase binding Cellular component cytoplasm endocytic vesicle membrane cytosol membrane nucleus ribosome myelin sheath cytosolic small ribosomal subunit nucleolus extracellular exosome plasma membrane nucleoplasm small ribosomal subunit endosome membrane extracellular space mitochondrial outer membrane endoplasmic reticulum quality control compartment vesicle endoplasmic reticulum membrane host cell Biological process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of epidermal growth factor receptor signaling pathway interstrand cross-link repair nucleotide-excision repair, DNA damage recognition positive regulation of canonical Wnt signaling pathway tumor necrosis factor-mediated signaling pathway regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway endosomal transport global genome nucleotide-excision repair NIK/NF-kappaB signaling G2/M transition of mitotic cell cycle stress-activated MAPK cascade transforming growth factor beta receptor signaling pathway macroautophagy negative regulation of canonical Wnt signaling pathway nucleotide-excision repair, DNA gap filling viral transcription error-free translesion synthesis regulation of tumor necrosis factor-mediated signaling pathway stimulatory C-type lectin receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway SRP-dependent cotranslational protein targeting to membrane JNK cascade regulation of transcription from RNA polymerase II promoter in response to hypoxia nucleotide-excision repair, DNA incision I-kappaB kinase/NF-kappaB signaling innate immune response Notch signaling pathway regulation of mRNA stability protein polyubiquitination negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II virion assembly positive regulation of NF-kappaB transcription factor activity anaphase-promoting complex-dependent catabolic process negative regulation of type I interferon production nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleotide-binding oligomerization domain containing signaling pathway intracellular transport of virus viral life cycle MyD88-dependent toll-like receptor signaling pathway error-prone translesion synthesis MAPK cascade fibroblast growth factor receptor signaling pathway ion transmembrane transport glycogen biosynthetic process positive regulation of apoptotic process translational initiation positive regulation of I-kappaB kinase/NF-kappaB signaling translesion synthesis transcription-coupled nucleotide-excision repair T cell receptor signaling pathway MyD88-independent toll-like receptor signaling pathway positive regulation of transcription by RNA polymerase II regulation of signal transduction by p53 class mediator positive regulation of epidermal growth factor receptor signaling pathway Wnt signaling pathway nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 5'-to lesion protein biosynthesis rRNA processing ERBB2 signaling pathway Wnt signaling pathway, planar cell polarity pathway nucleotide-excision repair, preincision complex assembly proteasome-mediated ubiquitin-dependent protein catabolic process protein folding negative regulation of G2/M transition of mitotic cell cycle protein ubiquitination protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process entry of bacterium into host cell transmembrane transport regulation of necroptotic process membrane organization endoplasmic reticulum mannose trimming cellular iron ion homeostasis regulation of hematopoietic stem cell differentiation protein targeting to peroxisome cytokine-mediated signaling pathway modification-dependent protein catabolic process interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6233 78294 Ensembl ENSG00000143947 ENSMUSG00000020460 UniProt P62979 P62983 RefSeq (mRNA) NM_002954 NM_001135592 NM_001177413 NM_001033865 NM_024277 RefSeq (protein) NP_001129064 NP_001170884 NP_002945 NP_001029037 NP_077239 Location (UCSC) Chr 2: 55.23 – 55.24 Mb Chr 11: 29.5 – 29.5 Mb PubMed search [3] [4]
Wikidata
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40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.^[5][6]

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.^[6]

References

Further reading

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