40S ribosomal protein S28

Protein-coding gene in the species Homo sapiens
RPS28
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC

Identifiers
AliasesRPS28, S28, DBA15, ribosomal protein S28, eS28
External IDsOMIM: 603685; MGI: 1859516; HomoloGene: 68150; GeneCards: RPS28; OMA:RPS28 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RPS28
Genomic location for RPS28
Band19p13.2Start8,321,158 bp[1]
End8,323,340 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RPS28
Genomic location for RPS28
Band17|17 B1Start34,038,001 bp[2]
End34,043,536 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • stromal cell of endometrium

  • skin of abdomen

  • right uterine tube

  • body of pancreas

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • canal of the cervix

  • body of stomach

  • minor salivary glands
Top expressed in
  • yolk sac

  • ganglionic eminence

  • uterus

  • bone marrow

  • urinary bladder

  • blastocyst

  • adrenal gland

  • islet of Langerhans

  • stomach

  • lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • protein binding
  • RNA binding
Cellular component
  • cytosol
  • ribosome
  • intracellular anatomical structure
  • small ribosomal subunit
  • extracellular exosome
  • nucleoplasm
  • cytosolic small ribosomal subunit
  • cytoplasm
  • endoplasmic reticulum
  • rough endoplasmic reticulum
  • polysomal ribosome
  • cytoplasmic side of rough endoplasmic reticulum membrane
Biological process
  • ribosome biogenesis
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • ribosomal small subunit biogenesis
  • ribosomal small subunit assembly
  • maturation of SSU-rRNA
  • protein biosynthesis
  • rRNA processing
  • cytoplasmic translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6234

54127

Ensembl

ENSG00000233927

ENSMUSG00000067288

UniProt

P62857

P62858

RefSeq (mRNA)

NM_001031

NM_016844
NM_001355384

RefSeq (protein)

NP_001022

NP_058540
NP_001342313

Location (UCSC)Chr 19: 8.32 – 8.32 MbChr 17: 34.04 – 34.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S28 is a protein that in humans is encoded by the RPS28 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000233927 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067288 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hori N, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (Nov 1993). "A cDNA sequence of human ribosomal protein, homologue of yeast S28". Nucleic Acids Res. 21 (18): 4394. doi:10.1093/nar/21.18.4394. PMC 310080. PMID 8415000.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPS28 ribosomal protein S28".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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