40S ribosomal protein S7

Protein-coding gene in the species Homo sapiens
RPS7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC

Identifiers
AliasesRPS7, DBA8, S7, ribosomal protein S7, eS7
External IDsOMIM: 603658; MGI: 1333818; HomoloGene: 107159; GeneCards: RPS7; OMA:RPS7 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for RPS7
Genomic location for RPS7
Band2p25.3Start3,575,260 bp[1]
End3,580,920 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for RPS7
Genomic location for RPS7
Band12|12 A2Start28,680,853 bp[2]
End28,685,952 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • rectum

  • lymph node

  • smooth muscle tissue

  • ganglionic eminence

  • uterine tube

  • skin of abdomen

  • canal of the cervix

  • placenta

  • anterior pituitary
Top expressed in
  • ganglionic eminence

  • lens

  • lip

  • yolk sac

  • thymus

  • morula

  • spleen

  • ovary

  • neural tube

  • mesencephalon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • protein binding
  • RNA binding
  • mRNA 3'-UTR binding
  • mRNA 5'-UTR binding
  • ubiquitin ligase inhibitor activity
  • protein kinase binding
  • poly(U) RNA binding
Cellular component
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • intracellular anatomical structure
  • microtubule organizing center
  • nucleolus
  • extracellular exosome
  • cytoskeleton
  • nucleus
  • nucleoplasm
  • extracellular matrix
  • cytoplasm
  • 90S preribosome
  • small-subunit processome
  • centrosome
  • cytosolic small ribosomal subunit
  • protein-containing complex
  • synapse
  • ribonucleoprotein complex
Biological process
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • ribosomal small subunit biogenesis
  • rRNA processing
  • protein biosynthesis
  • cytoplasmic translation
  • positive regulation of gene expression
  • protein stabilization
  • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
  • negative regulation of ubiquitin protein ligase activity
  • negative regulation of ubiquitin-dependent protein catabolic process
  • neural tube closure
  • cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6201

20115

Ensembl

ENSG00000171863

ENSMUSG00000061477

UniProt

P62081

P62082

RefSeq (mRNA)

NM_001011

NM_011300

RefSeq (protein)

NP_001002

NP_035430

Location (UCSC)Chr 2: 3.58 – 3.58 MbChr 12: 28.68 – 28.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.[5][6][7]

In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171863 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061477 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Annilo T, Laan M, Stahl J, Metspalu A (Jan 1996). "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Gene. 165 (2): 297–302. doi:10.1016/0378-1119(95)00576-R. PMID 8522193.
  6. ^ Gorbea C, Taillandier D, Rechsteiner M (Feb 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7" (PDF). J Biol Chem. 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621.
  7. ^ a b "Entrez Gene: RPS7 ribosomal protein S7".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID 8318536.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  • Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
  • Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
  • Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
  • Chen D, Zhang Z, Li M, et al. (2007). "Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function". Oncogene. 26 (35): 5029–37. doi:10.1038/sj.onc.1210327. PMID 17310983. S2CID 9239498.

External links

  • Overview of all the structural information available in the PDB for UniProt: P62081 (40S ribosomal protein S7) at the PDBe-KB.
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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
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