Timelotem

Chemical compound
  • none
Identifiers
  • 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine
CAS Number
  • 96306-34-2
PubChem CID
  • 65844
Chemical and physical dataFormulaC17H18FN3SMolar mass315.41 g·mol−13D model (JSmol)
  • Interactive image
  • CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4
InChI
  • InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3
  • Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N

Timelotem is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, timelotem has little or no activity at the GABAA receptor, but instead acts as an atypical antipsychotic drug with similar pharmacology and effects to the structurally related drug clozapine.[1] It has two enantiomers, but has only been studied as the racemic mix.

See also

  • Olanzapine

References

  1. ^ Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol". Life Sciences. 41 (16): 1909–14. doi:10.1016/0024-3205(87)90742-9. PMID 2889124.
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Benzodiazepines
1,4-Benzodiazepines
1,5-Benzodiazepines2,3-Benzodiazepines*TriazolobenzodiazepinesImidazobenzodiazepinesOxazolobenzodiazepinesThienodiazepinesThienotriazolodiazepinesThienobenzodiazepines*PyridodiazepinesPyridotriazolodiazepinesPyrazolodiazepinesPyrrolodiazepinesTetrahydroisoquinobenzodiazepinesPyrrolobenzodiazepines*Benzodiazepine prodrugs
* atypical activity profile (not GABAA receptor ligands)