Thienobenzodiazepine

Class of chemical compounds
General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups.
General structure of thienobenzodiazepines. Core is highlighted by black and color. Grey depicts accessory functional groups.

Thienobenzodiazepine is a heterocyclic compound containing a diazepine ring fused to a thiophene ring and a benzene ring. Thienobenzodiazepine forms the central core of pharmaceutical drugs including atypical antipsychotic olanzapine (Zyprexa) and antimuscarinic telenzepine. Thienobenzodiazepines act relatively selectively at the α2 subunit of the GABAA receptor.[1]

References

  1. ^ Bymaster, Frank P; Calligaro, David O; Falcone, Julie F; Marsh, Richard D; Moore, Nicholas A; Tye, Nicholas C; Seeman, Philip; Wong, David T (February 1996). "Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine". Neuropsychopharmacology. 4 (2): 87–96. doi:10.1016/0893-133X(94)00129-N. PMID 8822531 – via PubMed.
  • v
  • t
  • e
Benzodiazepines
1,4-Benzodiazepines
1,5-Benzodiazepines2,3-Benzodiazepines*TriazolobenzodiazepinesImidazobenzodiazepinesOxazolobenzodiazepinesThienodiazepinesThienotriazolodiazepinesThienobenzodiazepines*PyridodiazepinesPyridotriazolodiazepinesPyrazolodiazepinesPyrrolodiazepinesTetrahydroisoquinobenzodiazepinesPyrrolobenzodiazepines*Benzodiazepine prodrugs
* atypical activity profile (not GABAA receptor ligands)


Stub icon

This article about a heterocyclic compound is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e