Girisopam
Chemical compound
- none
- 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
- 82230-53-3
Y
- 71257
- 64387 Y
- 2LP301A921
- ChEMBL1915065
N
- DTXSID70231642
- Interactive image
- Clc3cccc(C\2=N\N=C(/Cc1c/2cc(OC)c(OC)c1)C)c3
InChI
- InChI=1S/C18H17ClN2O2/c1-11-7-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-5-4-6-14(19)8-12/h4-6,8-10H,7H2,1-3H3Y
- Key:VQYLGVVODFDFNK-UHFFFAOYSA-NY
N
Y (what is this?) (verify)Girisopam[1] (GYKI-51189, EGIS-5810) is a drug which is a 2,3-benzodiazepine derivative, related to tofisopam[2] and zometapine. It has selective anxiolytic action with no sedative, anticonvulsant or muscle relaxant effects.[2][3][4]
See also
- Benzodiazepine
References
- ^ US 4322346, Korosi J, Lang T, Szekely J, Andrasi F, Zolyomi G, Borsi J, Katali G, Hamori T, Gabriella S, Zsuz MN, Miglecz E, "5H-2,3-Benzodiazepine derivatives", issued 30 March 1982
- ^ a b Andrási F, Horváth K, Sineger E, Berzsenyi P, Borsy J, Kenessey A, Tarr M, Láng T, Kórösi J, Hámori T (October 1987). "Neuropharmacology of a new psychotropic 2,3-benzodiazepine". Arzneimittel-Forschung. 37 (10): 1119–24. PMID 2893623.
- ^ Horváth K, Andrási F, Botka P, Hámori T (1992). "Anxiolytic profile of girisopam and GYKI 52,322 (EGIS 6775). Comparison with chlordiazepoxide and buspirone". Acta Physiologica Hungarica. 79 (2): 153–61. PMID 1363928.
- ^ Horváth EJ, Salamon C, Bakonyi A, Fekete MI, Palkovits M (July 1999). "[(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site". Brain Research. Brain Research Protocols. 4 (2): 230–5. doi:10.1016/s1385-299x(99)00025-2. PMID 10446419.
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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