Syntaxin binding protein 3

Protein-coding gene in the species Homo sapiens

STXBP3

Identifiers

Aliases

STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3

External IDs

OMIM: 608339; MGI: 107362; HomoloGene: 5260; GeneCards: STXBP3; OMA:STXBP3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	108,746,674 bp^[1]
Band	1p13.3	End	108,809,523 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F3	Start	108,700,492 bp^[2]
Band	3\|3 F3	End	108,747,842 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus callosum

Achilles tendon

tibia

germinal epithelium

inferior ganglion of vagus nerve

monocyte

sural nerve

palpebral conjunctiva

subthalamic nucleus

visceral pleura

Top expressed in

ascending aorta

sciatic nerve

jejunum

aortic valve

retinal pigment epithelium

iris

triceps brachii muscle

conjunctival fornix

corneal stroma

ileum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	syntaxin-1 binding protein binding syntaxin binding
Cellular component	cytoplasm platelet alpha granule cytosol membrane tertiary granule plasma membrane basolateral plasma membrane specific granule apical plasma membrane extracellular exosome phagocytic vesicle presynapse
Biological process	protein to membrane docking protein heterooligomerization neutrophil degranulation insulin secretion vesicle docking involved in exocytosis response to insulin brain development negative regulation of calcium ion-dependent exocytosis protein transport platelet aggregation vesicle-mediated transport exocytosis transport cellular glucose homeostasis negative regulation of glucose import cellular response to interferon-gamma
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6814


20912

Ensembl


ENSG00000116266


ENSMUSG00000027882

UniProt


O00186


Q60770

RefSeq (mRNA)


NM_007269


NM_011504

RefSeq (protein)


NP_009200


NP_035634

Location (UCSC)

Chr 1: 108.75 – 108.81 Mb

Chr 3: 108.7 – 108.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.^[5]^[6]

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2^[7] and STX4.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116266 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027882 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID 10194441.
^ "Entrez Gene: STXBP3 syntaxin binding protein 3".
^ ^a ^b Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
^ Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (November 1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". The Journal of Neuroscience. 16 (21): 6695–702. doi:10.1523/JNEUROSCI.16-21-06695.1996. PMC 6579271. PMID 8824310.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB (February 2005). "Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression". The Journal of Biological Chemistry. 280 (5): 3178–84. doi:10.1074/jbc.M410044200. PMID 15576373.
Hodgkinson CP, Mander A, Sale GJ (June 2005). "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking". The Biochemical Journal. 388 (Pt 3): 785–93. doi:10.1042/BJ20041845. PMC 1183457. PMID 15707389.