SEC24A

Protein-coding gene in the species Homo sapiens
SEC24A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2NUP, 2NUT, 3EGD, 3EGX

Identifiers
AliasesSEC24A, SEC24 homolog A, COPII coat complex component
External IDsOMIM: 607183; MGI: 1924621; HomoloGene: 70131; GeneCards: SEC24A; OMA:SEC24A - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SEC24A
Genomic location for SEC24A
Band5q31.1Start134,648,785 bp[1]
End134,727,909 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SEC24A
Genomic location for SEC24A
Band11|11 B1.3Start51,583,091 bp[2]
End51,654,461 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • oocyte

  • parotid gland

  • oral cavity

  • secondary oocyte

  • tibia

  • corpus epididymis

  • trabecular bone

  • caput epididymis

  • periodontal fiber
Top expressed in
  • seminal vesicula

  • left lobe of liver

  • salivary gland

  • lacrimal gland

  • submandibular gland

  • body of femur

  • cumulus cell

  • parotid gland

  • ileum

  • pineal gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • zinc ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • endoplasmic reticulum membrane
  • membrane
  • Golgi membrane
  • endoplasmic reticulum
  • COPII vesicle coat
  • cytosol
  • ER to Golgi transport vesicle membrane
  • cytoplasmic vesicle
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • antigen processing and presentation of peptide antigen via MHC class I
  • COPII vesicle coating
  • positive regulation of protein secretion
  • protein transport
  • intracellular protein transport
  • vesicle-mediated transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • COPII-coated vesicle cargo loading
  • cholesterol homeostasis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10802

77371

Ensembl

ENSG00000113615

ENSMUSG00000036391

UniProt

O95486

Q3U2P1

RefSeq (mRNA)

NM_001252231
NM_021982

NM_001290785
NM_175255

RefSeq (protein)

NP_001239160
NP_068817

NP_001277714
NP_780464

Location (UCSC)Chr 5: 134.65 – 134.73 MbChr 11: 51.58 – 51.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene.[5] The protein belongs to a protein family that are homologous to yeast Sec24.[6] It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113615 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036391 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "SEC24 family, member A (S. cerevisiae)". Retrieved 2011-12-05.
  6. ^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (May 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochemical and Biophysical Research Communications. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.

Further reading

  • Mancias JD, Goldberg J (May 2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Molecular Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.
  • Wendeler MW, Paccaud JP, Hauri HP (March 2007). "Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum". EMBO Reports. 8 (3): 258–64. doi:10.1038/sj.embor.7400893. PMC 1808030. PMID 17255961.
  • Kirchhausen T (December 2000). "Three ways to make a vesicle". Nature Reviews. Molecular Cell Biology. 1 (3): 187–98. doi:10.1038/35043117. PMID 11252894. S2CID 205011168.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein transport protein Sec24A
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders
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