STX16

Protein-coding gene in the species Homo sapiens
STX16
Identifiers
AliasesSTX16, SYN16, syntaxin 16, SYN-16
External IDsOMIM: 603666 MGI: 1923396 HomoloGene: 2791 GeneCards: STX16
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for STX16
Genomic location for STX16
Band20q13.32Start58,651,253 bp[1]
End58,679,526 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for STX16
Genomic location for STX16
Band2|2 H4Start173,918,101 bp[2]
End173,941,564 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • sural nerve

  • corpus callosum

  • superficial temporal artery

  • pituitary gland

  • anterior pituitary

  • canal of the cervix

  • inferior ganglion of vagus nerve

  • secondary oocyte

  • monocyte
Top expressed in
  • hand

  • otolith organ

  • utricle

  • thymus

  • lens

  • cerebellar cortex

  • yolk sac

  • superior frontal gyrus

  • lateral hypothalamus

  • ventromedial nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • SNAP receptor activity
  • protein binding
  • syntaxin binding
  • SNARE binding
Cellular component
  • cytoplasm
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • intracellular membrane-bounded organelle
  • Golgi cisterna
  • focal adhesion
  • trans-Golgi network
  • SNARE complex
  • endoplasmic reticulum
  • perinuclear region of cytoplasm
  • cytosol
  • trans-Golgi network membrane
  • Golgi membrane
  • endomembrane system
  • integral component of synaptic vesicle membrane
Biological process
  • vesicle docking
  • retrograde transport, endosome to Golgi
  • protein transport
  • intracellular protein transport
  • vesicle fusion
  • Golgi ribbon formation
  • vesicle-mediated transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8675

228960

Ensembl

ENSG00000124222

ENSMUSG00000027522

UniProt

O14662

Q8BVI5

RefSeq (mRNA)
NM_001001433
NM_001001434
NM_001134772
NM_001134773
NM_001204868

NM_003763

NM_001102423
NM_001102424
NM_001102425
NM_172675
NM_001363029

NM_001363030
NM_001363031

RefSeq (protein)

NP_001001433
NP_001128244
NP_001128245
NP_001191797
NP_003754

NP_001095893
NP_001095894
NP_001095895
NP_766263
NP_001349958

NP_001349959
NP_001349960

Location (UCSC)Chr 20: 58.65 – 58.68 MbChr 2: 173.92 – 173.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.[5][6][7][8]

It has been associated with pseudohypoparathyroidism type Ib. Losing this gene causes loss of methylation at GNAS1 exon A/B.[7]

Interactions

STX16 has been shown to interact with VAMP4.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124222 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027522 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.
  6. ^ Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.
  7. ^ a b Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.
  8. ^ "Entrez Gene: STX16 syntaxin 16".
  9. ^ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

  • Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F (Aug 2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Research. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
  • Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
  • Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, Rizo J (Jul 2002). "How Tlg2p/syntaxin 16 'snares' Vps45". The EMBO Journal. 21 (14): 3620–31. doi:10.1093/emboj/cdf381. PMC 126126. PMID 12110575.
  • Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M (Dec 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. Bibcode:2003Sci...302.1960C. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
  • Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Amessou M, Fradagrada A, Falguières T, Lord JM, Smith DC, Roberts LM, Lamaze C, Johannes L (Apr 2007). "Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins". Journal of Cell Science. 120 (Pt 8): 1457–68. doi:10.1242/jcs.03436. PMC 1863825. PMID 17389686.


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Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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