GBLD-345
Chemical compound
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Formula | C21H21N5O2 |
Molar mass | 375.432 g·mol−1 |
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GBLD-345 is an anxiolytic drug used in scientific research, which acts as a non-selective, full-efficacy positive allosteric modulator of the GABAA receptor. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]
References
- ^ Davies LP, Barlin GB, Ireland SJ, Ngu MM (October 1992). "Substituted imidazo[1,2-b]pyridazines. New compounds with activity at central and peripheral benzodiazepine receptors". Biochemical Pharmacology. 44 (8): 1555–61. doi:10.1016/0006-2952(92)90472-U. PMID 1358075.
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Anxiolytics (N05B)
- Buspirone
- Gepirone
- Tandospirone
- Benzodiazepines: Adinazolam
- Alprazolam
- Bromazepam
- Camazepam
- Chlordiazepoxide
- Clobazam
- Clonazepam
- Clorazepate
- Clotiazepam
- Cloxazolam
- Diazepam#
- Ethyl loflazepate
- Etizolam
- Fludiazepam
- Halazepam
- Ketazolam
- Lorazepam#
- Medazepam
- Nordazepam
- Oxazepam
- Pinazepam
- Prazepam; Others: Alpidem‡
- Barbiturates (e.g., phenobarbital)
- Carbamates (e.g., meprobamate)
- Carisoprodol
- Chlormezanone‡
- Ethanol (alcohol)
- Etifoxine
(α2δ VDCC blockers)
- SSRIsTooltip Selective serotonin reuptake inhibitors (e.g., escitalopram)
- SNRIsTooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine)
- SARIsTooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone)
- TCAsTooltip Tricyclic antidepressants (e.g., clomipramine#)
- TeCAsTooltip Tetracyclic antidepressants (e.g., mirtazapine)
- MAOIsTooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine
- Bupropion
- Tianeptine
- Vilazodone
- Vortioxetine
(Antiadrenergics)
- Alpha-1 blockers (e.g., prazosin)
- Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine)
- Beta blockers (e.g., propranolol)
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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