Metaraminol

Pregnancy
categoryRoutes of
administrationIntravenous, endotrachealATC codeLegal statusLegal status Pharmacokinetic dataBioavailabilityn/aProtein binding~45%MetabolismLiverIdentifiersCAS NumberPubChem CIDIUPHAR/BPSDrugBankChemSpiderUNIIKEGGChEBIChEMBLCompTox Dashboard (EPA)Chemical and physical dataFormulaC₉H₁₃NO₂Molar mass167.208 g·mol⁻¹3D model (JSmol) ^NY (what is this?)  (verify)

Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α₁-adrenergic receptor agonist with some β-adrenergic effect.^[2] It is currently sold in its generic form by Slayback Pharma.^[3]

Pharmacology and use as a vasopressor

Metaraminol is given intravenously as either a bolus (often 0.5–1 mg doses) or as an infusion, usually via peripheral intravenous access. Metaraminol is commonly available as 10 mg in 1 mL, that requires dilution prior to administration (often made up to a 0.5 mg/mL solution), however pre-prepared syringes of metaraminol for bolus use for hypotension are also commonly available.^[4][5]

Pharmacodynamics

The dominant mechanism for the vasopressor action of metaraminol is indirect,^[6] with metaraminol displacing noradrenaline from neuronal vesicles in order for the noradrenaline to exert its vasopressor action.^[7] Metaraminol at higher doses may have direct alpha-adrenergic agonist and β₁ adrenergic agonist effects.^[6] However at doses common in clinical practice, the indirect α₁ adrenergic effects predominate, such that reflex bradycardia is a common side-effect.

Research

Metaraminol is also used in the treatment of priapism.^[8][9][10]

References

External links

• "Metaraminol". Drug Information Portal. U.S. National Library of Medicine.
• "Metaraminol bitartrate". Drug Information Portal. U.S. National Library of Medicine.