Metanephrine

Metanephrine
Names
IUPAC name
4-(1-hydroxy-2-methylamino-ethyl)-2-methoxy-phenol
Identifiers
CAS Number
  • 5001-33-2 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL775 checkY
ChemSpider
  • 19844 checkY
IUPHAR/BPS
  • 6644
MeSH Metanephrine
PubChem CID
  • 21100
UNII
  • 1ZE0530JEJ checkY
InChI
  • InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3 checkY
    Key: JWJCTZKFYGDABJ-UHFFFAOYSA-N checkY
  • InChI=1/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
    Key: JWJCTZKFYGDABJ-UHFFFAOYAB
  • Oc1ccc(cc1OC)C(O)CNC
Properties
Chemical formula
 C10H15NO3
Molar mass 197.231 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Metanephrine, also known as metadrenaline, is a metabolite of epinephrine (also known as adrenaline) created by action of catechol-O-methyl transferase on epinephrine. An article in the Journal of the American Medical Association, 2002, indicated that the measurement of plasma free levels of the metanephrines group of molecules (including metanephrine and normetanephrine) is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm.[1]

References

  1. ^ Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G (2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA. 287 (11): 1427–34. doi:10.1001/jama.287.11.1427. PMID 11903030. Free full text with registration


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