Arformoterol

Chemical compound

US DailyMed: Arformoterol

Routes of
administrationInhalationATC code

None

Legal statusLegal status

US: ℞-only^[1]

Pharmacokinetic dataProtein binding52–65%Elimination half-life26 hoursIdentifiers

IUPAC name

N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl) propan-2-yl]amino]ethyl] phenyl]formamide

CAS Number

67346-49-0^Y

PubChem CID

3083544

IUPHAR/BPS

7479

DrugBank

DB01274^Y

ChemSpider

2340731^Y

UNII

F91H02EBWT

KEGG

D07463
D02981

ChEBI

CHEBI:408174^Y

ChEMBL

ChEMBL1201137^N

CompTox Dashboard (EPA)

DTXSID1023077 DTXSID40110071, DTXSID1023077

Chemical and physical dataFormulaC₁₉H₂₄N₂O₄Molar mass344.411 g·mol⁻¹

InChI

InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1^Y
Key:BPZSYCZIITTYBL-YJYMSZOUSA-N^Y

^NY (what is this?) (verify)

Arformoterol, sold under the brand name Brovana among others, is a medication used for the treatment of chronic obstructive pulmonary disease (COPD).^[1]^[2]

It is a long-acting β₂ adrenoreceptor agonist (LABA) and it is the active (R,R)-(−)-enantiomer of formoterol.^[1] It was approved for medical use in the United States in October 2006.^[1] It is available as a generic medication.^[3]

Medical uses

Arformoterol is indicated for the maintenance treatment of bronchoconstriction in people with chronic obstructive pulmonary disease (COPD).^[1]

References

^ ^a ^b ^c ^d ^e "Brovana- arformoterol tartrate solution". DailyMed. 13 May 2021. Retrieved 4 March 2022.
^ Loh CH, Donohue JF, Ohar JA (March 2015). "Review of drug safety and efficacy of arformoterol in chronic obstructive pulmonary disease". Expert Opinion on Drug Safety. 14 (3): 463–72. doi:10.1517/14740338.2015.998196. PMID 25563342. S2CID 7767810.
^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.

External links

"Arformoterol". Drug Information Portal. U.S. National Library of Medicine.
"Arformoterol tartrate". Drug Information Portal. U.S. National Library of Medicine.

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short-acting β₂ agonists	Bitolterol Carbuterol Fenoterol Isoetarine Pirbuterol Procaterol Reproterol Rimiterol Salbutamol (albuterol)^#/Levosalbutamol (levalbuterol) Terbutaline Tulobuterol
Long-acting β₂ agonists	Bambuterol Clenbuterol Formoterol/Arformoterol Salmeterol Salmefamol
Ultra-long-acting β₂ agonists	Abediterol Carmoterol Indacaterol Olodaterol Vilanterol
Other	Epinephrine^# Hexoprenaline Isoprenaline (isoproterenol) Orciprenaline (metaproterenol)

Glucocorticoids

Anticholinergics/
muscarinic antagonist

Mast cell stabilizers

Xanthines

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast
Arachidonate 5-lipoxygenase inhibitors	Zileuton
Thromboxane receptor antagonists	Ramatroban Seratrodast
Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast