KIF19

Motor protein found in humans
KIF19
Identifiers
AliasesKIF19, KIF19A, kinesin family member 19
External IDsMGI: 2447024 HomoloGene: 17709 GeneCards: KIF19
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KIF19
Genomic location for KIF19
Band17q25.1Start74,326,210 bp[1]
End74,355,820 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for KIF19
Genomic location for KIF19
Band11|11 E2Start114,656,214 bp[2]
End114,681,565 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • sural nerve

  • spleen

  • hypothalamus

  • amygdala

  • caudate nucleus

  • putamen

  • bronchial epithelial cell

  • Brodmann area 9

  • substantia nigra
Top expressed in
  • islet of Langerhans

  • spermatocyte

  • hypothalamus

  • testicle

  • lens

  • ovary

  • spermatid

  • morula

  • quadriceps femoris muscle

  • olfactory bulb
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • microtubule motor activity
  • nucleotide binding
  • ATPase activity
  • plus-end-directed microtubule motor activity
  • ATP binding
Cellular component
  • cytoplasm
  • axoneme
  • cell projection
  • cilium
  • microtubule
  • cytoskeleton
  • kinesin complex
Biological process
  • microtubule-based movement
  • axonemal microtubule depolymerization
  • plus-end specific microtubule depolymerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

124602

286942

Ensembl

ENSG00000196169

ENSMUSG00000010021

UniProt

Q2TAC6

Q99PT9

RefSeq (mRNA)

NM_153209

NM_001102615

RefSeq (protein)

NP_694941

NP_001096085

Location (UCSC)Chr 17: 74.33 – 74.36 MbChr 11: 114.66 – 114.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin family member 19 (KIF19) is a protein in humans encoded by the KIF19 gene. It is part of the kinesin family of motor proteins.

Function

KIF19 is involved in cancer metastasis, as well as cell-cell and cell-matrix interactions.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196169 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010021 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eisenberg, Samuel C.; Dey, Abhinav; Birnbaum, Rayna; Sharp, David J. (2020-09-04). "The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion". doi:10.1101/2020.09.04.282657. S2CID 221589215. {{cite journal}}: Cite journal requires |journal= (help)
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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