KIFC1

Protein-coding gene in the species Homo sapiens
KIFC1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2REP

Identifiers
AliasesKIFC1, HSET, KNSL2, kinesin family member C1
External IDsOMIM: 603763; MGI: 2137414; HomoloGene: 83229; GeneCards: KIFC1; OMA:KIFC1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for KIFC1
Genomic location for KIFC1
Band6p21.32Start33,391,823 bp[1]
End33,409,896 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for KIFC1
Genomic location for KIFC1
Band17|17 A3.3Start27,136,065 bp[2]
End27,151,557 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • bone marrow

  • lymph node

  • appendix

  • stromal cell of endometrium

  • bone marrow cells

  • duodenum

  • placenta

  • rectum

  • thymus
Top expressed in
  • bone marrow

  • yolk sac

  • urethra

  • thymus

  • placenta

  • ganglionic eminence

  • main bronchus

  • spermatocyte

  • blood vessel

  • lens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • microtubule binding
  • ATPase activity
  • ATP binding
  • microtubule motor activity
  • minus-end-directed microtubule motor activity
Cellular component
  • cytoplasm
  • endosome
  • membrane
  • kinesin complex
  • spindle
  • microtubule organizing center
  • early endosome
  • microtubule
  • cytoskeleton
  • nucleus
  • mitotic spindle
Biological process
  • cell division
  • mitotic spindle assembly
  • spermatogenesis
  • mitotic sister chromatid segregation
  • cell cycle
  • mitotic metaphase plate congression
  • microtubule-based movement
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3833

16580

Ensembl

ENSG00000233450
ENSG00000204197
ENSG00000237649
ENSG00000056678

ENSMUSG00000024301

UniProt

Q9BW19

Q9QWT9

RefSeq (mRNA)

NM_002263

NM_016761
NM_053173

RefSeq (protein)

NP_002254

NP_001182227

Location (UCSC)Chr 6: 33.39 – 33.41 MbChr 17: 27.14 – 27.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.[5][6]

Function

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

References

  1. ^ a b c ENSG00000204197, ENSG00000237649, ENSG00000056678 GRCh38: Ensembl release 89: ENSG00000233450, ENSG00000204197, ENSG00000237649, ENSG00000056678 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024301 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics. 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466. S2CID 8880453.
  6. ^ "Entrez Gene: KIFC1 kinesin family member C1".

Further reading

  • Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–7011. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  • Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics. 49 (7–8): 644–652. doi:10.1007/s002510050660. PMID 10369922. S2CID 25729892.
  • Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis" (PDF). J. Cell Biol. 162 (5): 863–875. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
  • Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–172. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton. 64 (5): 377–389. doi:10.1002/cm.20190. PMID 17326138.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9BW19 (Human Kinesin-like protein KIFC1) at the PDBe-KB.


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