TUBGCP6

Protein-coding gene in the species Homo sapiens
TUBGCP6
Identifiers
AliasesTUBGCP6, GCP-6, GCP6, MCCRP, MCPHCR, MCCRP1, tubulin gamma complex associated protein 6
External IDsOMIM: 610053; MGI: 2146071; HomoloGene: 32477; GeneCards: TUBGCP6; OMA:TUBGCP6 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TUBGCP6
Genomic location for TUBGCP6
Band22q13.33Start50,217,689 bp[1]
End50,245,023 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TUBGCP6
Genomic location for TUBGCP6
Band15|15 E3Start88,982,560 bp[2]
End89,007,315 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • body of pancreas

  • sural nerve

  • right uterine tube

  • canal of the cervix

  • body of stomach

  • spleen

  • right adrenal gland
Top expressed in
  • cerebellar cortex

  • superior frontal gyrus

  • yolk sac

  • spermatocyte

  • esophagus

  • thymus

  • neural tube

  • lip

  • superior cervical ganglion

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • structural constituent of cytoskeleton
  • microtubule minus-end binding
  • gamma-tubulin binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • spindle pole
  • equatorial microtubule organizing center
  • membrane
  • microtubule organizing center
  • spindle pole body
  • microtubule
  • extracellular exosome
  • cytoskeleton
  • gamma-tubulin complex
  • gamma-tubulin small complex
Biological process
  • centrosome duplication
  • microtubule nucleation by interphase microtubule organizing center
  • mitotic spindle assembly
  • cytoplasmic microtubule organization
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • meiosis
  • mitotic cell cycle
  • spindle assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85378

328580

Ensembl

ENSG00000128159

ENSMUSG00000051786

UniProt

Q96RT7

G5E8P0

RefSeq (mRNA)

NM_001008658
NM_020461

NM_001163319

RefSeq (protein)

NP_065194

NP_001156791

Location (UCSC)Chr 22: 50.22 – 50.25 MbChr 15: 88.98 – 89.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128159 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051786 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
  6. ^ Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  7. ^ "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6".

Further reading

  • Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell. 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.


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