KIF14

Protein-coding gene in the species Homo sapiens
KIF14
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4OZQ

Identifiers
AliasesKIF14, MKS12, kinesin family member 14, MCPH20
External IDsOMIM: 611279; MGI: 1098226; HomoloGene: 8916; GeneCards: KIF14; OMA:KIF14 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KIF14
Genomic location for KIF14
Band1q32.1Start200,551,497 bp[1]
End200,620,751 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for KIF14
Genomic location for KIF14
Band1 E4|1 59.8 cMStart136,394,081 bp[2]
End136,459,249 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • trabecular bone

  • embryo

  • bone marrow

  • thymus

  • ganglionic eminence

  • stromal cell of endometrium

  • tibia

  • bone marrow cells

  • oral cavity
Top expressed in
  • secondary oocyte

  • spermatocyte

  • spermatid

  • yolk sac

  • morula

  • thymus

  • esophagus

  • lip

  • lens

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • tubulin binding
  • nucleotide binding
  • protein kinase binding
  • plus-end-directed microtubule motor activity
  • PDZ domain binding
  • microtubule motor activity
  • microtubule binding
  • ATP binding
  • protein binding
  • ATPase activity
Cellular component
  • spindle
  • cytoplasm
  • kinesin complex
  • nucleus
  • membrane
  • midbody
  • microtubule
  • plasma membrane
  • spindle midzone
  • cytoskeleton
  • cytosol
  • Flemming body
Biological process
  • negative regulation of integrin activation
  • cerebral cortex development
  • negative regulation of apoptotic process
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of neuron apoptotic process
  • hippocampus development
  • regulation of cell growth
  • cell division
  • substrate adhesion-dependent cell spreading
  • regulation of G1/S transition of mitotic cell cycle
  • cell proliferation in forebrain
  • regulation of G2/M transition of mitotic cell cycle
  • cerebellar granular layer structural organization
  • olfactory bulb development
  • microtubule depolymerization
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • cerebellar Purkinje cell layer structural organization
  • regulation of myelination
  • positive regulation of cell population proliferation
  • regulation of Rap protein signal transduction
  • cerebellar cortex development
  • positive regulation of cytokinesis
  • negative regulation of neuron apoptotic process
  • establishment of protein localization
  • regulation of cell migration
  • mitotic metaphase plate congression
  • regulation of cell maturation
  • microtubule-based movement
  • activation of protein kinase activity
  • regulation of cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9928

381293

Ensembl

ENSG00000118193

ENSMUSG00000041498

UniProt

Q15058

L0N7N1

RefSeq (mRNA)

NM_001305792
NM_014875

NM_001081258
NM_001287179

RefSeq (protein)

NP_001292721
NP_055690

NP_001274108

Location (UCSC)Chr 1: 200.55 – 200.62 MbChr 1: 136.39 – 136.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118193 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041498 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  6. ^ "Entrez Gene: KIF14 kinesin family member 14".

Further reading

  • Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. Bibcode:1997PNAS...94.9654N. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers". Oncogene. 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
  • Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
  • Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer". Int. J. Cancer. 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
  • Carleton M, Mao M, Biery M, et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1". Genes Chromosomes Cancer. 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872. S2CID 22499766.
  • Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
  • Corson TW, Zhu CQ, Lau SK, et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
  • Madhavan J, Coral K, Mallikarjuna K, et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.


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