Tridihexethyl

Chemical compound

A03AB08 (WHO)

Identifiers

IUPAC name

3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium

CAS Number

60-49-1^Y

PubChem CID

20299

DrugBank

DB00505^Y

ChemSpider

19124^Y

UNII

7HE50A367X

ChEBI

CHEBI:9701^Y

ChEMBL

ChEMBL1201354^N

CompTox Dashboard (EPA)

DTXSID0048553

Chemical and physical dataFormulaC₂₁H₃₆NO⁺Molar mass318.525 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

OC(c1ccccc1)(CC[N+](CC)(CC)CC)C2CCCCC2

InChI

InChI=1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1^Y
Key:NPRHVSBSZMAEIN-UHFFFAOYSA-N^Y

^NY (what is this?) (verify)

Tridihexethyl (which is commonly used as its chloride salt, tridihexethyl chloride) is an anticholinergic, antimuscarinic and antispasmodic drug. It may be used, usually in combination with other drugs, to treat acquired nystagmus^[1] or peptic ulcer disease.^[2] Many patients discontinue the drug because of unwanted side effects.

It is also known as Pathilon or Propethonum. ^[3]

References

^ Leigh RJ, Burnstine TH, Ruff RL, Kasmer RJ (November 1991). "Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride". Neurology. 41 (11): 1737–41. doi:10.1212/wnl.41.11.1737. PMID 1944902. S2CID 23270800.
^ "DB00505 (Tridihexethyl)". DrugBank.
^ "Tridihexethyl". Mongabay.com. Archived from the original on 2007-11-15.

Drugs for functional gastrointestinal disorders (A03)

Drugs for
functional
bowel
disorders

Antimuscarinics

Tertiary amino group	Oxyphencyclimine Camylofin Mebeverine Trimebutine Rociverine Dicycloverine Dihexyverine Difemerine Piperidolate
Quaternary ammonium compounds	Benzilone Mepenzolate Pipenzolate Glycopyrronium Oxyphenonium Penthienate Methantheline Propantheline Otilonium Tridihexethyl Isopropamide Hexocyclium Poldine Bevonium Diphemanil Tiemonium Prifinium Timepidium Fenpiverinium