TNFRSF19

Protein-coding gene in the species Homo sapiens
TNFRSF19
Identifiers
AliasesTNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19
External IDsOMIM: 606122; MGI: 1352474; HomoloGene: 8481; GeneCards: TNFRSF19; OMA:TNFRSF19 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for TNFRSF19
Genomic location for TNFRSF19
Band13q12.12Start23,570,370 bp[1]
End23,676,104 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for TNFRSF19
Genomic location for TNFRSF19
Band14|14 D1Start61,201,324 bp[2]
End61,283,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • skin of thigh

  • bronchial epithelial cell

  • skin of hip

  • mucosa of paranasal sinus

  • skin of abdomen

  • ventricular zone

  • right uterine tube

  • trachea

  • olfactory zone of nasal mucosa
Top expressed in
  • bronchus

  • calvaria

  • molar

  • main bronchus

  • body of femur

  • epithelium of bronchus

  • maxillary prominence

  • skin of external ear

  • upper jaw

  • vestibular sensory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • tumor necrosis factor-activated receptor activity
  • signaling receptor activity
  • protein binding
Cellular component
  • integral component of membrane
  • membrane
  • intracellular anatomical structure
  • plasma membrane
Biological process
  • hair follicle development
  • JNK cascade
  • apoptotic process
  • positive regulation of JNK cascade
  • tissue development
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • tumor necrosis factor-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55504

29820

Ensembl

ENSG00000127863

ENSMUSG00000060548

UniProt

Q9NS68

Q9JLL3

RefSeq (mRNA)

NM_001204458
NM_001204459
NM_018647
NM_148957
NM_001354985

NM_001164155
NM_013869

RefSeq (protein)

NP_001191387
NP_001191388
NP_061117
NP_683760
NP_001341914

NP_001157627
NP_038897

Location (UCSC)Chr 13: 23.57 – 23.68 MbChr 14: 61.2 – 61.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[5]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127863 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060548 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19".

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Kojima T, Morikawa Y, Copeland NG, et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles". J. Biol. Chem. 275 (27): 20742–7. doi:10.1074/jbc.M002691200. PMID 10764796.
  • Eby MT, Jasmin A, Kumar A, et al. (2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death". J. Biol. Chem. 275 (20): 15336–42. doi:10.1074/jbc.275.20.15336. PMID 10809768.
  • Naito A, Yoshida H, Nishioka E, et al. (2002). "TRAF6-deficient mice display hypohidrotic ectodermal dysplasia". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8766–71. Bibcode:2002PNAS...99.8766N. doi:10.1073/pnas.132636999. PMC 124373. PMID 12060722.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors". Neuron. 45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID 15694321.
  • Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron. 45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322.
  • Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target". Int. J. Cancer. 120 (6): 1304–10. doi:10.1002/ijc.22367. PMID 17187358.
  • Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol. 33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012. S2CID 36762956.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamilyIL 17 familyEnzyme-linked receptor


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e