IL17RB

Protein-coding gene in the species Homo sapiens
IL17RB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3VBC

Identifiers
AliasesIL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDsOMIM: 605458; MGI: 1355292; HomoloGene: 10287; GeneCards: IL17RB; OMA:IL17RB - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IL17RB
Genomic location for IL17RB
Band3p21.1Start53,846,568 bp[1]
End53,865,794 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for IL17RB
Genomic location for IL17RB
Band14 A3|14 18.39 cMStart29,718,092 bp[2]
End29,730,853 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney tubule

  • right lobe of liver

  • human kidney

  • mucosa of ileum

  • right hemisphere of cerebellum

  • glomerulus

  • amygdala

  • metanephric glomerulus

  • caudate nucleus

  • nucleus accumbens
Top expressed in
  • secondary oocyte

  • primary oocyte

  • thymus

  • zygote

  • right kidney

  • proximal tubule

  • pharynx

  • morula

  • vestibular membrane of cochlear duct

  • Paneth cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cytokine receptor activity
  • interleukin-17 receptor activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • extracellular region
  • cell surface
  • integral component of plasma membrane
  • membrane
  • plasma membrane
Biological process
  • defense response
  • positive regulation of inflammatory response
  • regulation of cell growth
  • interleukin-17-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55540

50905

Ensembl

ENSG00000056736

ENSMUSG00000015966

UniProt

Q9NRM6

Q9JIP3

RefSeq (mRNA)

NM_018725
NM_172234

NM_019583

RefSeq (protein)

NP_061195

NP_062529

Location (UCSC)Chr 3: 53.85 – 53.87 MbChr 14: 29.72 – 29.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[5][6][7]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000056736 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015966 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
  6. ^ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801. S2CID 27521628.
  7. ^ a b "Entrez Gene: IL17RB interleukin 17 receptor B".

Further reading

  • Schwandner R, Yamaguchi K, Cao Z (2000). "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction". J. Exp. Med. 191 (7): 1233–40. doi:10.1084/jem.191.7.1233. PMC 2193168. PMID 10748240.
  • Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J. Biol. Chem. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy". Clin. Cancer Res. 12 (7 Pt 1): 1954–5. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
  • Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen". Clin. Cancer Res. 12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019. S2CID 9930864.
  • Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer". J. Clin. Oncol. 24 (28): 4611–9. doi:10.1200/JCO.2006.06.6944. PMID 17008703.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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