Interleukin 11 receptor alpha subunit

Protein-coding gene in the species Homo sapiens
IL11RA
Identifiers
AliasesIL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDsOMIM: 600939; MGI: 109123; HomoloGene: 88705; GeneCards: IL11RA; OMA:IL11RA - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IL11RA
Genomic location for IL11RA
Band9p13.3Start34,652,162 bp[1]
End34,661,902 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for IL11RA
Genomic location for IL11RA
Band4 A5|4 22.73 cMStart42,656,001 bp[2]
End42,665,763 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • Descending thoracic aorta

  • right auricle

  • ascending aorta

  • granulocyte

  • muscle layer of sigmoid colon

  • right coronary artery

  • right hemisphere of cerebellum

  • left lobe of thyroid gland

  • left uterine tube
Top expressed in
  • granular layer of epidermis

  • spermatocyte

  • dental follicle

  • blood vessel

  • third ventricle

  • cartilage tissue

  • tracheobronchial tree

  • bronchus

  • tongue

  • dermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cytokine receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
  • interleukin-11 receptor activity
  • cytokine binding
  • interleukin-11 binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • external side of plasma membrane
  • receptor complex
Biological process
  • head development
  • embryo implantation
  • developmental process
  • cytokine-mediated signaling pathway
  • positive regulation of cell population proliferation
  • interleukin-11-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3590

16158

Ensembl

ENSG00000137070

ENSMUSG00000078735

UniProt

Q14626

P70225

RefSeq (mRNA)

NM_001142784
NM_004512
NM_147162

NM_010550

RefSeq (protein)

NP_001136256

NP_001092818
NP_001365603

Location (UCSC)Chr 9: 34.65 – 34.66 MbChr 4: 42.66 – 42.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[5]

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137070 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078735 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL11RA interleukin 11 receptor, alpha".

Further reading

  • Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): 2534–40. doi:10.1182/blood.V86.7.2534.bloodjournal8672534 (inactive 2024-05-13). PMID 7670098.{{cite journal}}: CS1 maint: DOI inactive as of May 2024 (link)
  • Chérel M, Sorel M, Apiou F, et al. (1996). "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics. 32 (1): 49–53. doi:10.1006/geno.1996.0075. PMID 8786120.
  • Van Leuven F, Stas L, Hilliker C, et al. (1996). "Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13". Genomics. 31 (1): 65–70. doi:10.1006/geno.1996.0010. PMID 8808281.
  • Magrangeas F, Pitiot G, Dubois S, et al. (1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution". J. Biol. Chem. 273 (26): 16005–10. doi:10.1074/jbc.273.26.16005. PMID 9632650.
  • Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11". J. Biol. Chem. 274 (9): 5755–61. doi:10.1074/jbc.274.9.5755. PMID 10026196.
  • Tacken I, Dahmen H, Boisteau O, et al. (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem. 265 (2): 645–55. doi:10.1046/j.1432-1327.1999.00755.x. PMID 10504396.
  • Campbell CL, Jiang Z, Savarese DM, Savarese TM (2001). "Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma". Am. J. Pathol. 158 (1): 25–32. doi:10.1016/S0002-9440(10)63940-5. PMC 1850253. PMID 11141475.
  • Cork BA, Tuckerman EM, Li TC, Laird SM (2003). "Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro". Mol. Hum. Reprod. 8 (9): 841–8. doi:10.1093/molehr/8.9.841. PMID 12200462.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Karpovich N, Chobotova K, Carver J, et al. (2003). "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75–80. doi:10.1093/molehr/gag012. PMC 1626582. PMID 12569176.
  • Kiessling S, Muller-Newen G, Leeb SN, et al. (2004). "Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells". J. Biol. Chem. 279 (11): 10304–15. doi:10.1074/jbc.M312757200. PMID 14701802.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zurita AJ, Troncoso P, Cardó-Vila M, et al. (2004). "Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer". Cancer Res. 64 (2): 435–9. doi:10.1158/0008-5472.CAN-03-2675. PMID 14744752.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tsimanis A, Shtalrid M, Shvidel L, et al. (2005). "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma. 45 (11): 2315–9. doi:10.1080/10428190412331283161. PMID 15512823. S2CID 27011485.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Karube K, Ohshima K, Suzumiya J, et al. (2006). "Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha". Ann. Oncol. 17 (1): 110–6. doi:10.1093/annonc/mdj064. PMID 16291580.
  • Hanavadi S, Martin TA, Watkins G, et al. (2006). "Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer". Ann. Surg. Oncol. 13 (6): 802–8. doi:10.1245/ASO.2006.05.028. PMID 16614887. S2CID 5693500.
  • Yoshizaki A, Nakayama T, Yamazumi K, et al. (2006). "Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells". Int. J. Oncol. 29 (4): 869–76. doi:10.3892/ijo.29.4.869. PMID 16964382.
  • Nakayama T, Yoshizaki A, Izumida S, et al. (2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells". Int. J. Oncol. 30 (4): 825–33. doi:10.3892/ijo.30.4.825. PMID 17332920.
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