TSPAN6

Protein-coding gene in humans
TSPAN6
Identifiers
AliasesTSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDsOMIM: 300191; MGI: 1926264; HomoloGene: 20700; GeneCards: TSPAN6; OMA:TSPAN6 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for TSPAN6
Genomic location for TSPAN6
BandXq22.1Start100,627,108 bp[1]
End100,639,991 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for TSPAN6
Genomic location for TSPAN6
BandX|X E3Start132,791,817 bp[2]
End132,799,178 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • parotid gland

  • bronchial epithelial cell

  • nasal epithelium

  • epithelium of nasopharynx

  • tibia

  • mucosa of paranasal sinus

  • olfactory zone of nasal mucosa

  • mucosa of colon

  • mucosa of sigmoid colon
Top expressed in
  • saccule

  • transitional epithelium of urinary bladder

  • otic placode

  • otic vesicle

  • endocardial cushion

  • atrioventricular valve

  • medial ganglionic eminence

  • molar

  • abdominal wall

  • neural tube
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signal transducer activity
Cellular component
  • integral component of membrane
  • integral component of plasma membrane
  • extracellular exosome
  • membrane
Biological process
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • negative regulation of NIK/NF-kappaB signaling
  • cell surface receptor signaling pathway
  • negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7105

56496

Ensembl

ENSG00000000003

ENSMUSG00000067377

UniProt

O43657

O70401

RefSeq (mRNA)

NM_001278740
NM_001278741
NM_001278742
NM_001278743
NM_003270

NM_019656

RefSeq (protein)

NP_001265669
NP_001265670
NP_001265671
NP_001265672
NP_003261

n/a

Location (UCSC)Chr X: 100.63 – 100.64 MbChr X: 132.79 – 132.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000000003 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067377 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics. 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095.
  6. ^ a b "Entrez Gene: TSPAN6 tetraspanin 6".

Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
  • Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • v
  • t
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ArrestinMembrane-spanning 4A
  • MS4A1
  • MS4A2
  • MS4A3
  • MS4A4A
  • MS4A4E
  • MS4A5
  • MS4A6A
  • MS4A6E
  • MS4A7
  • MS4A8B
  • MS4A9
  • MS4A10
  • MS4A12
  • MS4A13
  • MS4A14
  • MS4A15
  • MS4A18
MyelinPulmonary surfactantTetraspanin
Other/ungrouped
see also other cell membrane protein disorders


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