ARR3

Protein-coding gene in humans

ARR3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1XEH, 2A34

Identifiers

Aliases

ARR3, ARRX, cArr, arrestin 3 retinal (X-arrestin), arrestin 3, MYP26

External IDs

OMIM: 301770; MGI: 2159617; HomoloGene: 3182; GeneCards: ARR3; OMA:ARR3 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq13.1	Start	70,268,305 bp^[1]
Band	Xq13.1	End	70,281,840 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X C3	Start	99,649,103 bp^[2]
Band	X\|X C3	End	99,662,099 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

retina

retinal pigment epithelium

sural nerve

stromal cell of endometrium

rectum

mononuclear cell

monocyte

skin of abdomen

skin of leg

Top expressed in

neural layer of retina

epithelium of lens

morula

retinal pigment epithelium

embryo

blastocyst

primary visual cortex

zygote

superior frontal gyrus

outer nuclear layer

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphoprotein binding opsin binding protein binding G protein-coupled receptor binding
Cellular component	photoreceptor inner segment cytoplasm photoreceptor outer segment synapse
Biological process	regulation of protein phosphorylation endocytosis signal transduction visual perception response to stimulus G protein-coupled receptor internalization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


407


170735

Ensembl


ENSG00000120500


ENSMUSG00000060890

UniProt


P36575


Q9EQP6

RefSeq (mRNA)


NM_004312


NM_133205

RefSeq (protein)


NP_004303


NP_573468

Location (UCSC)

Chr X: 70.27 – 70.28 Mb

Chr X: 99.65 – 99.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Arrestin-C, also known as retinal cone arrestin-3, is a protein that in humans is encoded by the ARR3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120500 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060890 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murakami A, Yajima T, Sakuma H, McLaren MJ, Inana G (Dec 1993). "X-arrestin: a new retinal arrestin mapping to the X chromosome". FEBS Lett. 334 (2): 203–9. doi:10.1016/0014-5793(93)81712-9. PMID 8224247.
^ "Entrez Gene: ARR3 arrestin 3, retinal (X-arrestin)".

Craft CM, Whitmore DH, Wiechmann AF (1994). "Cone arrestin identified by targeting expression of a functional family". J. Biol. Chem. 269 (6): 4613–9. doi:10.1016/S0021-9258(17)41820-5. PMID 8308033.
Sakuma H, Inana G, Murakami A, et al. (1996). "Immunolocalization of X-arrestin in human cone photoreceptors". FEBS Lett. 382 (1–2): 105–10. doi:10.1016/0014-5793(96)00163-9. PMID 8612728.
ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker". Cell. 95 (4): 563–73. doi:10.1016/S0092-8674(00)81623-2. PMC 4428171. PMID 9827808.
Orsini MJ, Benovic JL (1999). "Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms". J. Biol. Chem. 273 (51): 34616–22. doi:10.1074/jbc.273.51.34616. PMID 9852134.
Sakuma H, Murakami A, Fujimaki T, Inana G (1999). "Isolation and characterization of the human X-arrestin gene". Gene. 224 (1–2): 87–95. doi:10.1016/S0378-1119(98)00510-1. PMID 9931451.
John SK, Smith JE, Aguirre GD, Milam AH (2000). "Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa". Mol. Vis. 6: 204–15. PMID 11063754.
Chen Z, Dupré DJ, Le Gouill C, et al. (2002). "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc.M110058200. PMID 11729201.
Kim YM, Barak LS, Caron MG, Benovic JL (2002). "Regulation of arrestin-3 phosphorylation by casein kinase II". J. Biol. Chem. 277 (19): 16837–46. doi:10.1074/jbc.M201379200. PMID 11877451.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhu X, Li A, Brown B, et al. (2002). "Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors". Mol. Vis. 8: 462–71. PMID 12486395.
Zhang H, Cuenca N, Ivanova T, et al. (2003). "Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6". Invest. Ophthalmol. Vis. Sci. 44 (7): 2858–67. doi:10.1167/iovs.03-0072. hdl:10045/13046. PMID 12824223.
Krishnamurthy H, Galet C, Ascoli M (2004). "The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation". Mol. Cell. Endocrinol. 204 (1–2): 127–40. doi:10.1016/S0303-7207(03)00088-1. PMID 12850288. S2CID 25222855.
Zhu X, Brown B, Li A, et al. (2003). "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina". J. Neurosci. 23 (14): 6152–60. doi:10.1523/JNEUROSCI.23-14-06152.2003. PMC 6740345. PMID 12853434.
Ermakova NA, Alekberova ZS, Prokaeva TB (2004). "Autoimmunity to S-Antigen and Retinal Vasculitis in Patients with Behçet's Disease". Adamantiades-Behçet's Disease. Advances in Experimental Medicine and Biology. Vol. 528. pp. 279–81. doi:10.1007/0-306-48382-3_56. ISBN 978-0-306-47757-7. PMID 12918707.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.