KCNA10

Protein-coding gene in the species Homo sapiens

KCNA10

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2AFL

Identifiers

Aliases

KCNA10, Kcn1, Kv1.8, potassium voltage-gated channel subfamily A member 10

External IDs

OMIM: 602420; MGI: 3037820; HomoloGene: 4054; GeneCards: KCNA10; OMA:KCNA10 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	110,517,217 bp^[1]
Band	1p13.3	End	110,519,175 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 F2.3\|3 46.64 cM	Start	107,090,372 bp^[2]
Band	3 F2.3\|3 46.64 cM	End	107,103,037 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stomach

testicle

Top expressed in

quadriceps femoris muscle

skeletal muscle tissue

hypothalamus

spleen

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	intracellular cyclic nucleotide activated cation channel activity voltage-gated ion channel activity ion channel activity potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity outward rectifier potassium channel activity
Cellular component	plasma membrane membrane voltage-gated potassium channel complex integral component of membrane
Biological process	ion transport transmembrane transport potassium ion transport protein homooligomerization regulation of ion transmembrane transport potassium ion transmembrane transport potassium ion export across plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3744


242151

Ensembl


ENSG00000143105


ENSMUSG00000042861

UniProt


Q16322


B2RQA1

RefSeq (mRNA)


NM_005549


NM_001081140

RefSeq (protein)


NP_005540


NP_001074609

Location (UCSC)

Chr 1: 110.52 – 110.52 Mb

Chr 3: 107.09 – 107.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily A member 10 also known as K_v1.8 is a protein that in humans is encoded by the KCNA10 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143105 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042861 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv1.8+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNA10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin