CACNA1G

Protein-coding gene in the species Homo sapiens

CACNA1G

Identifiers

Aliases

CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G, SCA42ND

External IDs

OMIM: 604065; MGI: 1201678; HomoloGene: 22544; GeneCards: CACNA1G; OMA:CACNA1G - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.33	Start	50,560,715 bp^[1]
Band	17q21.33	End	50,627,474 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 D	Start	94,299,217 bp^[2]
Band	11\|11 D	End	94,365,024 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

endothelial cell

prefrontal cortex

orbitofrontal cortex

dorsolateral prefrontal cortex

postcentral gyrus

superior frontal gyrus

canal of the cervix

Brodmann area 9

hypothalamus

Top expressed in

cerebellar cortex

medial dorsal nucleus

superior frontal gyrus

cerebellar vermis

medial geniculate nucleus

lateral geniculate nucleus

superior colliculus

subiculum

vas deferens

cingulate gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated calcium channel activity calcium channel activity scaffold protein binding voltage-gated ion channel activity ion channel activity voltage-gated calcium channel activity involved in AV node cell action potential voltage-gated calcium channel activity involved SA node cell action potential low voltage-gated calcium channel activity voltage-gated sodium channel activity
Cellular component	integral component of membrane membrane voltage-gated calcium channel complex cytoplasm plasma membrane
Biological process	membrane depolarization during action potential calcium ion import regulation of membrane potential regulation of ion transmembrane transport regulation of atrial cardiac muscle cell membrane depolarization ion transport regulation of heart rate positive regulation of calcium ion-dependent exocytosis transmembrane transport action potential response to nickel cation calcium ion transport chemical synaptic transmission AV node cell to bundle of His cell signaling regulation of heart rate by cardiac conduction SA node cell action potential AV node cell action potential SA node cell to atrial cardiac muscle cell signaling membrane depolarization during AV node cell action potential calcium ion transmembrane transport membrane depolarization during SA node cell action potential cardiac muscle cell action potential involved in contraction neuronal action potential sodium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8913


12291

Ensembl


ENSG00000006283


ENSMUSG00000020866

UniProt


O43497


n/a

RefSeq (mRNA)

NM_001256324 NM_001256325 NM_001256326 NM_001256327 NM_001256328
NM_001256329 NM_001256330 NM_001256331 NM_001256332 NM_001256333 NM_001256334 NM_001256359 NM_001256360 NM_001256361 NM_018896 NM_198376 NM_198377 NM_198378 NM_198379 NM_198380 NM_198382 NM_198383 NM_198384 NM_198385 NM_198386 NM_198387 NM_198388 NM_198396 NM_198397


NM_001112813 NM_001177888 NM_001177890 NM_009783

RefSeq (protein)

NP_001243253 NP_001243254 NP_001243255 NP_001243256 NP_001243257
NP_001243258 NP_001243259 NP_001243260 NP_001243261 NP_001243262 NP_001243263 NP_001243288 NP_001243289 NP_001243290 NP_061496 NP_938190 NP_938191 NP_938192 NP_938193 NP_938194 NP_938196 NP_938197 NP_938198 NP_938199 NP_938200 NP_938201 NP_938202 NP_938406


n/a

Location (UCSC)

Chr 17: 50.56 – 50.63 Mb

Chr 11: 94.3 – 94.37 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca_v3.1 is a protein which in humans is encoded by the CACNA1G gene.^[5]^[6]^[7] It is one of the primary targets in the pharmacology of absence seizure.

Function

Ca_v3.1 is a type of low-voltage-activated calcium channel, also known as "T-type" for its transient on and off.^[5] It is expressed in thalamocortical relay nucleus, and is responsible for the slow-wave sleep and absence seizure.^[8] During a slow-wave sleep, Ca_v3.1 is put into burst mode, and a self-sustaining synchronous cycle between cortex and thalamus is formed, sensory inputs are isolated from cortex; while awake the thalamus should instead relay sensory inputs from outside the central nervous system. The mechanism of absence seizure has a lot in common with slow-wave sleep. Therefore, a blocker that inhibits the burst mode activation of Ca_v3.1 is effective in treating absence seizures. Common drugs including ethosuximide, as well as trimethadione.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^{[§ 1]}

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Nicotine Activity on Chromaffin Cells edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
^ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.
^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.
^ ^a ^b Kopecky, Benjamin J.; Liang, Ruqiang; Bao, Jianxin (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". Pflügers Archiv. 466 (4): 757–765. doi:10.1007/s00424-014-1454-x. ISSN 0031-6768. PMC 4005039. PMID 24563219.

External links

CACNA1G+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNA1G genome location and CACNA1G gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin