CACNG4

Protein-coding gene in the species Homo sapiens

CACNG4

Identifiers

Aliases

CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4

External IDs

OMIM: 606404; MGI: 1859167; HomoloGene: 8674; GeneCards: CACNG4; OMA:CACNG4 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q24.2	Start	66,964,707 bp^[1]
Band	17q24.2	End	67,033,398 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E1	Start	107,623,183 bp^[2]
Band	11\|11 E1	End	107,685,383 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

nucleus accumbens

putamen

caudate nucleus

amygdala

hypothalamus

entorhinal cortex

endothelial cell

inferior olivary nucleus

Brodmann area 46

Top expressed in

otic placode

saccule

habenula

nucleus accumbens

ganglionic eminence

olfactory bulb

dorsomedial hypothalamic nucleus

superior frontal gyrus

superior cervical ganglion

ciliary body

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	voltage-gated ion channel activity channel regulator activity calcium channel activity voltage-gated calcium channel activity calcium channel regulator activity ionotropic glutamate receptor binding
Cellular component	endocytic vesicle membrane plasma membrane membrane voltage-gated calcium channel complex integral component of membrane integral component of plasma membrane AMPA glutamate receptor complex somatodendritic compartment cell surface postsynaptic density cell body postsynaptic density membrane L-type voltage-gated calcium channel complex glutamatergic synapse integral component of postsynaptic density membrane
Biological process	regulation of AMPA receptor activity regulation of ion transmembrane transport calcium ion transport ion transport transmission of nerve impulse membrane depolarization calcium ion transmembrane transport response to cocaine positive regulation of AMPA receptor activity regulation of postsynaptic neurotransmitter receptor activity positive regulation of synaptic transmission, glutamatergic neurotransmitter receptor transport, postsynaptic endosome to lysosome postsynaptic neurotransmitter receptor diffusion trapping neurotransmitter receptor internalization cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


27092


54377

Ensembl


ENSG00000075461


ENSMUSG00000020723

UniProt


Q9UBN1


Q9JJV4

RefSeq (mRNA)


NM_014405


NM_019431

RefSeq (protein)


NP_055220


NP_062304

Location (UCSC)

Chr 17: 66.96 – 67.03 Mb

Chr 11: 107.62 – 107.69 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.^[5]^[6]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075461 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020723 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Burgess DL, Davis CF, Gefrides LA, Noebels JL (Jan 2000). "Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication". Genome Res. 9 (12): 1204–13. doi:10.1101/gr.9.12.1204. PMC 311002. PMID 10613843.
^ ^a ^b "Entrez Gene: CACNG4 calcium channel, voltage-dependent, gamma subunit 4".

External links

CACNG4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNG4 genome location and CACNG4 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin