| SMAD7 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ | | |
| Ідентифікатори |
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| Символи | SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7 |
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| Зовнішні ІД | OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7 |
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| Пов'язані генетичні захворювання |
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| колоректальний рак[1] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• beta-catenin binding
• type I transforming growth factor beta receptor binding
• collagen binding
• I-SMAD binding
• activin binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• зв'язування з іоном металу
• GO:0001948, GO:0016582 protein binding
• ubiquitin protein ligase binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Клітинна компонента | • цитоплазма
• центросома
• transcription regulator complex
• клітинна мембрана
• внутрішньоклітинний
• нуклеоплазма
• catenin complex
• клітинне ядро
• fibrillar center
• гіалоплазма
• GO:0009327 protein-containing complex
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| Біологічний процес | • cellular response to transforming growth factor beta stimulus
• regulation of ventricular cardiac muscle cell membrane depolarization
• pathway-restricted SMAD protein phosphorylation
• ureteric bud development
• GO:0009373 regulation of transcription, DNA-templated
• adherens junction assembly
• positive regulation of cell-cell adhesion
• ventricular septum morphogenesis
• regulation of epithelial to mesenchymal transition
• negative regulation of peptidyl-threonine phosphorylation
• negative regulation of transcription by competitive promoter binding
• response to laminar fluid shear stress
• protein stabilization
• regulation of activin receptor signaling pathway
• GO:1901227 negative regulation of transcription by RNA polymerase II
• negative regulation of transforming growth factor beta receptor signaling pathway
• BMP signaling pathway
• negative regulation of DNA-binding transcription factor activity
• negative regulation of pathway-restricted SMAD protein phosphorylation
• negative regulation of BMP signaling pathway
• ventricular cardiac muscle tissue morphogenesis
• negative regulation of protein ubiquitination
• negative regulation of cell migration
• negative regulation of ubiquitin-protein transferase activity
• artery morphogenesis
• negative regulation of peptidyl-serine phosphorylation
• regulation of cardiac muscle contraction
• positive regulation of protein ubiquitination
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• negative regulation of epithelial to mesenchymal transition
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• regulation of transforming growth factor beta receptor signaling pathway
• transcription, DNA-templated
• transforming growth factor beta receptor signaling pathway
• protein deubiquitination
• negative regulation of T cell cytokine production
• negative regulation of T-helper 17 type immune response
• negative regulation of T-helper 17 cell differentiation
• cellular response to leukemia inhibitory factor
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_005904
NM_001190821
NM_001190822
NM_001190823 |
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| RefSeq (білок) | | NP_001177750
NP_001177751
NP_001177752
NP_005895 |
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| Локус (UCSC) | Хр. 18: 48.92 – 48.95 Mb | Хр. 18: 75.5 – 75.53 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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