TNP2

Protein-coding gene in the species Homo sapiens
TNP2
Identifiers
AliasesTNP2, TP2, transition protein 2 (during histone to protamine replacement), transition protein 2
External IDsOMIM: 190232; MGI: 98785; HomoloGene: 3958; GeneCards: TNP2; OMA:TNP2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for TNP2
Genomic location for TNP2
Band16p13.13Start11,267,748 bp[1]
End11,269,533 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for TNP2
Genomic location for TNP2
Band16 A1|16 5.83 cMStart10,605,800 bp[2]
End10,606,524 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right coronary artery

  • human musculoskeletal system

  • muscular system

  • muscle

  • muscle

  • prefrontal cortex

  • male reproductive gland

  • prostate

  • connective tissue
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • morula

  • skeletal muscle tissue

  • ascending aorta

  • thymus

  • islet of Langerhans

  • pituitary gland

  • adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • metal ion binding
  • zinc ion binding
Cellular component
  • male germ cell nucleus
  • nucleosome
  • nucleus
  • chromosome
Biological process
  • multicellular organism development
  • cell differentiation
  • spermatogenesis
  • acrosome reaction
  • penetration of zona pellucida
  • positive regulation of protein processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7142

21959

Ensembl

ENSG00000178279

ENSMUSG00000043050

UniProt

Q05952

P11378

RefSeq (mRNA)

NM_005425

NM_013694

RefSeq (protein)

NP_005416

NP_038722

Location (UCSC)Chr 16: 11.27 – 11.27 MbChr 16: 10.61 – 10.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear transition protein 2 is a protein that in humans is encoded by the TNP2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178279 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043050 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.
  6. ^ Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
  7. ^ "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

Further reading

  • Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression". Genomics. 14 (2): 377–83. doi:10.1016/S0888-7543(05)80229-0. PMID 1385303.
  • Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent". Biochemistry. 34 (15): 5143–50. doi:10.1021/bi00015a027. PMID 7711033.
  • Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition". J. Biol. Chem. 269 (49): 31067–73. doi:10.1016/S0021-9258(18)47391-7. PMID 7983046.
  • Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus". J. Biol. Chem. 268 (4): 2932–6. doi:10.1016/S0021-9258(18)53863-1. PMID 8428967.
  • Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2". Biochemistry. 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
  • Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
  • Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man". Nature. 403 (6767): 304–9. Bibcode:2000Natur.403..304W. doi:10.1038/35002070. PMID 10659848. S2CID 3136139.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin". J. Biol. Chem. 278 (32): 29471–7. doi:10.1074/jbc.M304545200. PMID 12775710.
  • Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
  • Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.


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