TNP1

Protein-coding gene in the species Homo sapiens
TNP1
Identifiers
AliasesTNP1, TP1, transition protein 1
External IDsOMIM: 190231; MGI: 98784; HomoloGene: 136517; GeneCards: TNP1; OMA:TNP1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for TNP1
Genomic location for TNP1
Band2q35Start216,859,458 bp[1]
End216,860,064 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TNP1
Genomic location for TNP1
Band1 C3|1 36.94 cMStart73,054,233 bp[2]
End73,055,068 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • cerebellar vermis

  • caput epididymis

  • corpus epididymis

  • right coronary artery

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • right uterine tube

  • canal of the cervix

  • right lobe of liver
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • entorhinal cortex

  • interventricular septum

  • plantaris muscle

  • extensor digitorum longus muscle

  • corneal stroma

  • morula

  • extraocular muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
Cellular component
  • male germ cell nucleus
  • nucleosome
  • chromosome
  • nucleus
Biological process
  • multicellular organism development
  • single strand break repair
  • flagellated sperm motility
  • chromatin remodeling
  • spermatid nucleus differentiation
  • cell differentiation
  • spermatid nucleus elongation
  • nucleosome disassembly
  • negative regulation of transcription, DNA-templated
  • sexual reproduction
  • spermatogenesis
  • spermatid development
  • positive regulation of protein processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7141

21958

Ensembl

ENSG00000118245

ENSMUSG00000026182

UniProt

P09430

P10856

RefSeq (mRNA)

NM_003284

NM_009407

RefSeq (protein)

NP_003275

NP_033433

Location (UCSC)Chr 2: 216.86 – 216.86 MbChr 1: 73.05 – 73.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118245 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026182 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics. 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
  6. ^ "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Further reading

  • Meistrich ML, Mohapatra B, Shirley CR, Zhao M (2004). "Roles of transition nuclear proteins in spermiogenesis". Chromosoma. 111 (8): 483–8. doi:10.1007/s00412-002-0227-z. PMID 12743712. S2CID 28866607.
  • Chirat F, Martinage A, Briand G, et al. (1991). "Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants" (PDF). Eur. J. Biochem. 198 (1): 13–20. doi:10.1111/j.1432-1033.1991.tb15980.x. PMID 2040274.
  • Baskaran R, Rao MR (1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J. Biol. Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
  • Kleene KC, Borzorgzadeh A, Flynn JF, et al. (1988). "Nucleotide sequence of a cDNA clone encoding mouse transition protein 1". Biochim. Biophys. Acta. 950 (2): 215–20. doi:10.1016/0167-4781(88)90013-9. PMID 3382664.
  • Luerssen H, Hoyer-Fender S, Engel W (1988). "The nucleotide sequence of human transition protein 1 cDNA". Nucleic Acids Res. 16 (15): 7723. doi:10.1093/nar/16.15.7723. PMC 338445. PMID 3412903.
  • Akama K, Kojima S, Nakano M, et al. (1994). "The amino acid sequence and phosphorylation sites of a boar transition protein 1". Biochem. Mol. Biol. Int. 32 (2): 349–57. PMID 8019440.
  • Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
  • Yu YE, Zhang Y, Unni E, et al. (2000). "Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4683–8. Bibcode:2000PNAS...97.4683Y. doi:10.1073/pnas.97.9.4683. PMC 18293. PMID 10781074.
  • Siffroi JP, Alfonsi MF, Dadoune JP (2001). "Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids". Italian Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia. 103 (4 Suppl 1): 65–74. PMID 11315969.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
  • Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.


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