PTPN21

Protein-coding gene in the species Homo sapiens

PTPN21

Identifiers

Aliases

PTPN21, PTPD1, PTPRL10, protein tyrosine phosphatase, non-receptor type 21, protein tyrosine phosphatase non-receptor type 21

External IDs

OMIM: 603271; MGI: 1344406; HomoloGene: 5110; GeneCards: PTPN21; OMA:PTPN21 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q31.3	Start	88,465,778 bp^[1]
Band	14q31.3	End	88,555,007 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 E	Start	98,643,000 bp^[2]
Band	12\|12 E	End	98,703,664 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of thigh

secondary oocyte

skin of hip

lower lobe of lung

skin of abdomen

right lung

right ventricle

lactiferous duct

left testis

right testis

Top expressed in

zygote

secondary oocyte

primary oocyte

neural layer of retina

medial head of gastrocnemius muscle

sciatic nerve

extraocular muscle

muscle of thigh

cardiac muscles

internal carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphoprotein phosphatase activity hydrolase activity phosphatase activity protein binding protein tyrosine phosphatase activity
Cellular component	cytoplasm cytoskeleton
Biological process	protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11099


24000

Ensembl


ENSG00000070778


ENSMUSG00000021009

UniProt


Q16825


Q62136

RefSeq (mRNA)


NM_007039


NM_001146199 NM_011877

RefSeq (protein)


NP_008970


n/a

Location (UCSC)

Chr 14: 88.47 – 88.56 Mb

Chr 12: 98.64 – 98.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.^[6]

Interactions

PTPN21 has been shown to interact with BMX^[7] and KIF1C.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070778 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021009 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Møller NP, Møller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A (Sep 1994). "Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain". Proc Natl Acad Sci USA. 91 (16): 7477–81. Bibcode:1994PNAS...91.7477M. doi:10.1073/pnas.91.16.7477. PMC 44424. PMID 7519780.
^ ^a ^b "Entrez Gene: PTPN21 protein tyrosine phosphatase, non-receptor type 21".
^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (Dec 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
^ Dorner C, Ciossek T, Müller S, Møller PH, Ullrich A, Lammers R (Aug 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J. Biol. Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.

Zeitlin AA, Heward JM, Brand OJ, Newby PR, Franklyn JA, Gough SC, Simmonds MJ (2007). "Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease". Clin. Endocrinol. 65 (3): 380–4. doi:10.1111/j.1365-2265.2006.02608.x. PMID 16918960. S2CID 19532757.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Cardone L, Carlucci A, Affaitati A, Livigni A, DeCristofaro T, Garbi C, Varrone S, Ullrich A, Gottesman ME, Avvedimento EV, Feliciello A (2004). "Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling". Mol. Cell. Biol. 24 (11): 4613–26. doi:10.1128/MCB.24.11.4613-4626.2004. PMC 416429. PMID 15143158.
Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (2001). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
Tokuchi H, Higashitsuji H, Nishiyama H, Nonoguchi K, Nagao T, Xue JH, Itoh K, Ogawa O, Fujita J (2000). "Expression of protein tyrosine phosphatase PTP-RL10 and its isoform in the mouse testis". Int. J. Urol. 6 (11): 572–7. doi:10.1046/j.1442-2042.1999.611108.x. PMID 10585123. S2CID 38524556.
Dorner C, Ciossek T, Müller S, Møller PH, Ullrich A, Lammers R (1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J. Biol. Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.
Higashitsuji H, Arii S, Furutani M, Imamura M, Kaneko Y, Takenawa J, Nakayama H, Fujita J (1995). "Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1". Oncogene. 10 (2): 407–14. PMID 7838537.

Esterase: protein tyrosine phosphatases (EC 3.1.3.48)

Class I

Classical PTPs

Receptor type PTPs	PTPRA PTPRB PTPRC PTPRD PTPRE PTPRF PTPRG PTPRH PTPRJ PTPRK PTPRM PTPRN PTPRN2 PTPRO PTPRQ PTPRR PTPRS PTPRT PTPRU PTPRZ1 PTPRZ2
Non receptor type PTPs	PTPN1 PTPN2 PTPN3 PTPN4 PTPN5 PTPN6 PTPN7 PTPN9 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN20 PTPN21 PTPN22 PTPN23

VH1-like or
dual specific
phosphatases
(DSPs)

MAPK phosphatases (MKPs)	DUSP1 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 DUSP10 DUSP16 MK-STYX
Slingshots	SSH1 SSH2 SSH3
PRLs	PTP4A1 PTP4A2 PTP4A3
CDC14s	CDC14A CDC14B CDKN3 PTP9Q22
Atypical DSPs	DUSP3 DUSP11 DUSP12 DUSP13A DUSP13B DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP22 DUSP23 DUSP24 DUSP25 DUSP26 DUSP27 EMP2A RNGTT STYX
Phosphatase and tensin homologs (PTENs)	PTEN TPIP TPTE TNS TENC1
Myotubularins	MTM1 MTMR2 MTMR3 MTMR4 MTMR5 MTMR6 MTMR7 MTMR8 MTMR9 MTMR10 MTMR11 MTMR12 MTMR13 MTMR14 MTMR15