Mofebutazone
Chemical compound
- M01AA02 (WHO) M02AA02 (WHO)
- 4-butyl-1-phenylpyrazolidine-3,5-dione
- 2210-63-1 Y
- 16639
- 15776 N
- SPW36WUI5Z
- D07262 Y
- CHEBI:76252 N
- DTXSID4023331
- Interactive image
- CCCCC1C(=O)NN(C1=O)c2ccccc2
InChI
- InChI=1S/C13H16N2O2/c1-2-3-9-11-12(16)14-15(13(11)17)10-7-5-4-6-8-10/h4-8,11H,2-3,9H2,1H3,(H,14,16) N
- Key:REOJLIXKJWXUGB-UHFFFAOYSA-N N
Mofebutazone (or monophenylbutazone) is a drug used for joint and muscular pain.[1][2] It is a 3,5-pyrazolinedione derivative.
The drug binds to plasma albumin and competes with drugs such as coumarin anticoagulants, indomethacin and glucocorticoids.
References
- ^ Kassem MA, Schulte KE (1984-07-01). "Pharmacokinetics of [4-14C] mofebutazone after oral administration in man". European Journal of Drug Metabolism and Pharmacokinetics. 9 (3): 223–227. doi:10.1007/BF03189645. PMID 6519123. S2CID 10985688.
- ^ Paradies HH (December 1987). "Structure of phenylbutazone and mofebutazone in the crystalline state and in solution". Journal of Pharmaceutical Sciences. 76 (12): 920–929. doi:10.1002/jps.2600761217. PMID 3440938.
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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