Indobufen

Chemical compound

Identifiers

CAS Number

PubChem CID

ChemSpider

UNII

KEGG

ChEMBL

CompTox Dashboard (EPA)

ECHA InfoCard100.058.496

Chemical and physical dataFormulaC₁₈H₁₇NO₃Molar mass295.338 g·mol⁻¹3D model (JSmol)

InChI

InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)^N
Key:AYDXAULLCROVIT-UHFFFAOYSA-N^N

^NY (what is this?) (verify)

Indobufen is a platelet aggregation inhibitor.^[1] It acts as a reversible cyclooxygenase inhibitor.^[2]

References

^ The Merck Index (12th ed.). p. 4991.
^ Eligini S, Violi F, Banfi C, Barbieri SS, Brambilla M, Saliola M, et al. (January 2006). "Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism". Cardiovascular Research. 69 (1): 218–26. doi:10.1016/j.cardiores.2005.07.013. PMID 16154551.

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§ Tirofiban
ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor
Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil
COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal
Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§
Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal
Other	Cloricromen Ditazole Vorapaxar

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide
Direct Xa inhibitors ("xabans")	Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban