Ibrolipim
Names | |
---|---|
Preferred IUPAC name Diethyl ({4-[(4-bromo-2-cyanophenyl)carbamoyl]phenyl}methyl)phosphonate | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChemSpider |
|
ECHA InfoCard | 100.162.319 |
KEGG |
|
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C19H20BrN2O4P |
Molar mass | 451.25 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Ibrolipim (NO-1886) is a cholesterol lowering drug from the statin family, which acts as a lipoprotein lipase activator. The discovery of the "statin" mevalonic acid synthesis inhibitors focused new attention on control of blood lipid levels as a measure to stave off heart disease. A number of compounds have been found that treat elevated lipid levels by other diverse mechanisms. The phosphonic acid derivative ibrolipim is believed to lower those levels by accelerating fatty acid oxidation.[1]
References
- ^ Yin W, Tsutsumi K (2003). "Lipoprotein lipase activator NO-1886". Cardiovascular Drug Reviews. 21 (2): 133–42. doi:10.1111/j.1527-3466.2003.tb00111.x. PMID 12847564.
- v
- t
- e
Major chemical drug groups – based upon the Anatomical Therapeutic Chemical Classification System
/ metabolism (A)
- stomach acid
- Antacids
- H2 antagonists
- Proton-pump inhibitors
- Antiemetics
- Laxatives
- Antidiarrhoeals / Antipropulsives
- Anti-obesity drugs
- Diabetes medication
- Vitamins
- Dietary minerals
forming organs (B)
system (C)
system (G)
system (H)
infestations (J, P, QI)
(L01–L02)
(L03–L04)
and joints (M)
nervous system (N)
- Analgesics
- Anesthetics
- Anorectics
- Anti-ADHD agents
- Antiaddictives
- Anticonvulsants
- Antidementia agents
- Antidepressants
- Antimigraine agents
- Antiparkinson agents
- Antipsychotics
- Anxiolytics
- Aphrodisiacs
- Depressants
- Entactogens
- Entheogens
- Euphoriants
- Hallucinogens
- Hypnotics / Sedatives
- Mood stabilizers
- Neuroprotectives
- Nootropics
- Neurotoxins
- Orexigenics
- Serenics
- Stimulants
- Wakefulness-promoting agents
system (R)
- Decongestants
- Bronchodilators
- Cough medicines
- H1 antagonists
- Drugs
- Pharmacological classification systems
- ATC codes
- Medicine portal