Glyceronephosphate O-acyltransferase

glyceronephosphate O-acyltransferase

Identifiers

Symbol

GNPAT

NCBI gene

8443

HGNC

4416

OMIM

602744

RefSeq

NM_014236

UniProt

O15228

Other data

EC number

2.3.1.42

Locus

Chr. 1 q42

Search for
Structures	Swiss-model
Domains	InterPro

Glyceronephosphate O-acyltransferase is an enzyme associated with rhizomelic chondrodysplasia punctata type 2.^[1]

The gene encoding it, GNPAT, is located on chromosome 1 on the plus strand. The gene C1orf131 is located directly upstream of it, and the closest downstream gene is EXOC8.^[2]

References

^ Velišek J, Cejpek K (2011). "Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids". Czech J. Food Sci. 24 (6): 241–254. doi:10.17221/3321-CJFS. S2CID 73576606.
^ "GNPAT glyceronephosphate O-acyltransferase [ Homo sapiens (human) ]". Gene. National Center for Biotechnology Information. 26 January 2024. Gene ID 8443. Retrieved 27 February 2024.

External links

glycerone-phosphate+O-acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Peroxisomal and lysosomal proteins

Enzymes

Mevalonate kinase
Catalase
Acetyl-CoA C-acyltransferase
Glyceronephosphate O-acyltransferase
Alkylglycerone phosphate synthase
Phytanoyl-CoA dioxygenase
HSD17B4
AMACR

Transporters

SLC27A2

Structure/Peroxin

LAMP

see also intermediates, disorders

v t e Transferases: acyltransferases (EC 2.3)
2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5
2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII
2.3.3: converted into alkyl on transfer	Citrate synthase Decylcitrate synthase Citrate (Re)-synthase Decylhomocitrate synthase 2-methylcitrate synthase 2-ethylmalate synthase 3-ethylmalate synthase ATP citrate lyase Malate synthase HMG-CoA synthase HMGCS2 2-hydroxyglutarate synthase 3-propylmalate synthase 2-isopropylmalate synthase Homocitrate synthase Sulfoacetaldehyde acetyltransferase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)