2-acylglycerol-3-phosphate O-acyltransferase

In enzymology, a 2-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.52) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate ${\displaystyle \rightleftharpoons }$ CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase. This enzyme is also called 2-acylglycerophosphate acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

• Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38 (1): 25–31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123.