ALDH3B1

Protein-coding gene in the species Homo sapiens

ALDH3B1

Identifiers

Aliases

ALDH3B1, ALDH4, ALDH7, aldehyde dehydrogenase 3 family member B1

External IDs

OMIM: 600466; MGI: 1914939; HomoloGene: 73890; GeneCards: ALDH3B1; OMA:ALDH3B1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	68,008,578 bp^[1]
Band	11q13.2	End	68,029,282 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	3,963,491 bp^[2]
Band	19\|19 A	End	3,979,808 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

right uterine tube

olfactory zone of nasal mucosa

nasal epithelium

monocyte

right lung

mucosa of paranasal sinus

granulocyte

thoracic diaphragm

beta cell

Top expressed in

granulocyte

spermatid

Epithelium of choroid plexus

right kidney

right lung lobe

stroma of bone marrow

duodenum

tibiofemoral joint

seminiferous tubule

jejunum

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	3-chloroallyl aldehyde dehydrogenase activity protein binding oxidoreductase activity aldehyde dehydrogenase [NAD(P)+ activity] aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular component	vesicle membrane plasma membrane extracellular exosome secretory granule membrane specific granule membrane cytoplasm cytosol
Biological process	ethanol catabolic process lipid metabolism aldehyde catabolic process sphingolipid biosynthetic process cellular aldehyde metabolic process cellular response to oxidative stress metabolism alcohol metabolic process neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


221


67689

Ensembl


ENSG00000006534


ENSMUSG00000024885

UniProt


P43353 Q9BUJ8


Q80VQ0

RefSeq (mRNA)


NM_001290059 NM_000694 NM_001030010 NM_001161473 NM_001290058


NM_026316

RefSeq (protein)


NP_000685 NP_001025181 NP_001154945 NP_001276987 NP_001276988


NP_080592

Location (UCSC)

Chr 11: 68.01 – 68.03 Mb

Chr 19: 3.96 – 3.98 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Aldehyde dehydrogenase 3 family, member B1 also known as ALDH3B1 is an enzyme that in humans is encoded by the ALDH3B1 gene.^[5]^[6]

Function

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb that is highly expressed in kidney and lung. The functional significance of this gene and the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006534 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024885 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
^ Hsu LC, Chang WC, Yoshida A (Apr 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
^ "Entrez Gene: ALDH3B1".

External links

Human ALDH3B1 genome location and ALDH3B1 gene details page in the UCSC Genome Browser.

Sun X, Jia Y, Zhang X, Xu Q, Shen Y, Li Y (Jun 2005). "Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method". Science in China Series C: Life Sciences. 48 (3): 263–9. doi:10.1007/bf03183620. PMID 16092759. S2CID 19136391.
Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
Marchitti SA, Orlicky DJ, Vasiliou V (May 2007). "Expression and initial characterization of human ALDH3B1". Biochemical and Biophysical Research Communications. 356 (3): 792–8. doi:10.1016/j.bbrc.2007.03.046. PMC 1899873. PMID 17382292.
Saito A, Kawamoto M, Kamatani N (Jun 2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046.
Wang Y, Hu Y, Fang Y, Zhang K, Yang H, Ma J, Xu Q, Shen Y (Jun 2009). "Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia". Biological Psychiatry. 65 (12): 1048–54. doi:10.1016/j.biopsych.2008.11.027. PMID 19159868. S2CID 25166866.
Yoshida A, Rzhetsky A, Hsu LC, Chang C (Feb 1998). "Human aldehyde dehydrogenase gene family". European Journal of Biochemistry. 251 (3): 549–57. doi:10.1046/j.1432-1327.1998.2510549.x. PMID 9490025.