ALDH1L2

Protein-coding gene in humans

ALDH1L2

Identifiers

Aliases

ALDH1L2, mtFDH, aldehyde dehydrogenase 1 family member L2

External IDs

OMIM: 613584; MGI: 2444680; HomoloGene: 51942; GeneCards: ALDH1L2; OMA:ALDH1L2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q23.3	Start	105,019,784 bp^[1]
Band	12q23.3	End	105,107,643 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 C1	Start	83,323,314 bp^[2]
Band	10\|10 C1	End	83,370,004 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tibia

body of pancreas

stromal cell of endometrium

pancreatic epithelial cell

parotid gland

Achilles tendon

tendon of biceps brachii

islet of Langerhans

bone marrow cells

Descending thoracic aorta

Top expressed in

parotid gland

calvaria

lacrimal gland

body of femur

fossa

submandibular gland

atrium

belly cord

pancreas

islet of Langerhans

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hydroxymethyl-, formyl- and related transferase activity formyltetrahydrofolate dehydrogenase activity oxidoreductase activity catalytic activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Cellular component	extracellular exosome cytoplasm mitochondrion mitochondrial matrix nucleus
Biological process	one-carbon metabolic process biosynthesis 10-formyltetrahydrofolate catabolic process metabolism folic acid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


160428


216188

Ensembl


ENSG00000136010


ENSMUSG00000020256

UniProt


Q3SY69


Q8K009

RefSeq (mRNA)


NM_001034173


NM_153543

RefSeq (protein)


NP_001029345


NP_705771

Location (UCSC)

Chr 12: 105.02 – 105.11 Mb

Chr 10: 83.32 – 83.37 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.^[5]^[6] ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020256 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ Ota T, Suzuki Y, Nishikawa T, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
^ Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase." J Biol Chem. 2010 Jul 23;285(30):23056-63.
^ Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA. "Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahdyrofolate dehydrogenase." Chem Biol Interact. 2011 May 30;191(1-3):129-36.