ADAMTS10

Protein-coding gene in the species Homo sapiens
ADAMTS10
Identifiers
AliasesADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDsOMIM: 608990; MGI: 2449112; HomoloGene: 81940; GeneCards: ADAMTS10; OMA:ADAMTS10 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ADAMTS10
Genomic location for ADAMTS10
Band19p13.2Start8,580,240 bp[1]
End8,610,735 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for ADAMTS10
Genomic location for ADAMTS10
Band17|17 B1Start33,743,178 bp[2]
End33,772,756 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • ascending aorta

  • cerebellar vermis

  • vena cava

  • parotid gland

  • popliteal artery

  • left coronary artery

  • left uterine tube

  • canal of the cervix

  • body of tongue
Top expressed in
  • ascending aorta

  • aortic valve

  • left lung

  • left lung lobe

  • external carotid artery

  • internal carotid artery

  • cerebellar cortex

  • body of femur

  • right lung

  • molar
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • peptidase activity
  • metalloendopeptidase activity
  • protein binding
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • molecular function
Cellular component
  • microfibril
  • extracellular region
  • extracellular matrix
  • collagen-containing extracellular matrix
Biological process
  • proteolysis
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81794

224697

Ensembl

ENSG00000142303

ENSMUSG00000024299

UniProt

Q9H324

P58459

RefSeq (mRNA)

NM_001282352
NM_030957

NM_172619
NM_001329143
NM_001329147
NM_001329151
NM_001329152

NM_001329153
NM_001329154
NM_001329202
NM_001329203

RefSeq (protein)

NP_001269281
NP_112219

NP_001316072
NP_001316076
NP_001316080
NP_001316081
NP_001316082

NP_001316083
NP_001316131
NP_001316132
NP_766207

Location (UCSC)Chr 19: 8.58 – 8.61 MbChr 17: 33.74 – 33.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[5]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142303 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024299 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10".

Further reading

  • Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130.
  • Faivre L, Dollfus H, Lyonnet S, et al. (2004). "Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome". Am. J. Med. Genet. A. 123 (2): 204–7. doi:10.1002/ajmg.a.20289. PMID 14598350. S2CID 13600027.
  • Apte SS (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family". Int. J. Biochem. Cell Biol. 36 (6): 981–5. doi:10.1016/j.biocel.2004.01.014. PMID 15094112.
  • Faivre L, Mégarbané A, Alswaid A, et al. (2002). "Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2". Hum. Genet. 110 (4): 366–70. doi:10.1007/s00439-002-0689-3. PMID 11941487. S2CID 10463979.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
  • Somerville RP, Jungers KA, Apte SS (2005). "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation". J. Biol. Chem. 279 (49): 51208–17. doi:10.1074/jbc.M409036200. PMID 15355968.
  • Charrier L, Yan Y, Driss A, et al. (2005). "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G346–53. doi:10.1152/ajpgi.00262.2004. PMID 15358598.
  • Dagoneau N, Benoist-Lasselin C, Huber C, et al. (2005). "ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome". Am. J. Hum. Genet. 75 (5): 801–6. doi:10.1086/425231. PMC 1182109. PMID 15368195.

External links

  • GeneReviews/NIH/NCBI/UW entry on Weill-Marchesani Syndrome
  • The MEROPS online database for peptidases and their inhibitors: M12.235
  • Human ADAMTS10 genome location and ADAMTS10 gene details page in the UCSC Genome Browser.


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